between four and 105 (Fig.1b). On average soL1R burden was 30 per cancer, approximately tenfold more frequent than that observed in normal colorectal clones. The soL1R rate in colorectal carcinomas was 3.47 per 1,000 EPMs, which is around threefold higher than in normal colorectal epithel...
Lymphoid aggregates are present, and one at the boundary of the melanoma and normal dermis is marked with an asterisk (*) and is shown on the inset of the right panel. In the pure desmoplastic melanomas, PD-L1 expression was observed on lymphocytes (green arrow on inset) and macrophages ...
Supplementary Fig.4i–l; Fig.4i–k). While SOX10+ cells are found within these tumors, they are sparse and the majority did not co-localize with tdTOM (Fig.4i–k; Supplementary Fig.4u). Similarly, dCKO tdTOM+ tumors are predominantly GFAP+, and very few, if any, were SOX10+ (...
An important feature of the L1 regularization method is the ability to generate sparse matrices of feature weight coefficients, i.e., the coefficients of some features become zero, so that feature selection can be achieved based on feature weights. Therefore L1 regularization is often used for fea...
L1-norm is well-known to favor well-localized or sparse distributions compared to L2-norm (least-squares) fitted estimates. Methods: We present a linear programming approach that performs L1-norm fitting and penalization of the current pattern (L1L1) to control the number of non-zero currents....
This algorithm makes the network structure sparse, with some smaller weights that can be eventually removed. Meanwhile, the convergence of this algorithm is proved under some reasonable conditions. The proposed algorithms have been tested for the convergence speed, the convergence rate and the ...
Interestingly, we found that these treatments also re-established cognitive functions in Bmal1cKO mice to normal levels, whereas, similar to previous reports, did not augment the DI in control animals45,48 (Fig. 7e and Supplementary Fig. 11). This result implies that mnemonic deficits observed ...
Specifically, if an L1-optimal control problem is normal (see Remark 1 of Section 2, as well as [10]), then its optimal solution is also the optimal sparse, “hands-off” solution. Despite the aforementioned advantages, investigation of L1-optimal control in the literature is not as ...
After being grown under normal conditions for 6 weeks, the whole plants were subjected to drought stress by stopping watering. Twelve days after inducing stress, the plants were rehydrated and observed for recovery. For water-loss measurements, the third leaf from the top was detached from ...
1. All the tested extracts (HEX, DCM, DCM:MeOH and MeOH) had sparse inhibitory effect on α-glucosidase activity (IC50 = 5752.1, 1936.5, 1235.2 and 1495.2 µg/mL, respectively), which was not comparable to acarbose (IC50 = 10.6 µg/mL. For DPP-IV, the hexane and DCM:...