Kyte-Doolittle hydrophobicity scaleMacromolecular dockingProtein-protein interactionsStructureHADDOCK is one of the few docking programs that can explicitly account for water molecules in the docking process. It
Here, we introduce a simple water-mediated amino acid鈥揳mino acid contact probability scale derived from the Kyte-Doolittle hydrophobicity scale and assess its performance on the largest high-resolution dataset developed to date for solvated docking. Both scales yield high-quality docking results. ...