Since the ligand-induced conformational effect on the CSF1R could be the key understanding how the inhibitor triggered the CSF1R inhibition, however, the information about how inhibitor affected the CSF1R structurally remain unknown. In this study, we utilized in silico methods to visualize the sign...
Prior to docking analysis, co-crystallized heteroatoms and water molecules were removed from the crystal structure to provide the receptor coordinate using AutoDock Tool (ADT) version 4.1. All polar hydrogen atoms were added to mimic hydrogen bond interaction. Three dimensional structures of (−)-...