a, control; b, TRAIL (75 ng/ml); c, TRAIL (75 ng/ml) + kurarinone (5 µM); and d, kurarinone (5 µM). (C) Kurarinone (5 µM)-mediated increase in TRAIL-induced cell death was determined in the presence or absence of 100 µM of caspase inhibitors by crystal ...
Microscopic analysis showed that TRAIL (75 ng/ml) alone induced cell death of about 15%, and TRAIL co-treated with 5 μM kurarinone further elevated cell death to 70%, while kurarinone alone did not demonstrate a significant cytotoxic effect (Figures 1A and 1B). Cell death occurs via ...