palladium-catalyzed coupling of aryl,alkenyl,and alkyl Grignard reagents with aryl and alkenyl tosylates.The resulting biaryls,vinylarenes,and alkylarenes were isolated in good to excellent yield.These couplings were conducted with a nearly equimolar ratio of the two reactants,and many examples were...
Kumada couplingHakuna Kumada: Several efficient Kumada cross-coupling protocols of functionalized arylmagnesium halides and functionalized aryl and alkyl halides have been recently reported, including the first examples of the catalytic asymmetric Kumada coupling of racemic secondary alkyl halides. These ...
Nonetheless, the examples shown later do take some steps toward a more environmentally friendly reaction by using heterogeneous catalysts and reducing the amount of additives needed for the reaction. During a study of amination reactions, Lipshutz and Tasler showed that the Kumada coupling can be perf...
In the examples of amido NHC complexes [16], the NH protons were activated and the nitrogen atom was coordinated to the metal center to form bidentate or tetradentate complexes. Palladium and platinum aryl amine functionalized [C, N] type complexes were reported previously. But nickel complex ...
Pd-catalyzed Kumada coupling reaction of tetrachloroethylene and Grignard reagents was effective for the formation of diarylacetylenes as simple and convenient reaction, in which diarylacetylenes were successfully obtained in up to 82% yields and 14 examples were demonstrated. In addition, the current ...
Despite considerable progress in the field, examples of the transition-metal-catalyzed Kumada cross-coupling of an alkyl electrophile with a Grignard reagent are much less abundant and are more limited. The products are generally modified alkanes, a carbonyl group in the substrates can often not be...
The KTC cross-coupling reactions were also performed under similar Pd(OAc)(2)/SPhos conditions (11 examples, 50-98% yield). Application to a useful pharmacophore containing a cyclopropane structure was investigated, wherein distinctive (E)-and (Z)-stereochemical difference between XPhos and S...
A broad range of electronically‐varied aryl tosylates, including bis‐tosylates, underwent this transformation, and many examples are suitable at mild room temperature conditions. The combination of Ar?X cross‐coupling with the facile Ar?OH activation/cross‐coupling strategy permits for orthogonal ...
A broad range of electronically‐varied aryl tosylates, including bis‐tosylates, underwent this transformation, and many examples are suitable at mild room temperature conditions. The combination of Ar?X cross‐coupling with the facile Ar?OH activation/cross‐coupling strategy permits for orthogonal ...