Ku70/80 蛋白是一种在细胞核中起重要作用的蛋白复合物,由两个亚单位 Ku70 和 Ku80 组成,属于非同向性端连接(NHEJ)DNA修复通路的关键成分。Ku70/80 蛋白在DNA修复中起到关键的保护作用,Ku70/80蛋白的功能异常或缺失可能导致DNA损伤的累积和基因组不稳定性,进而增加致病风险。因此,研究Ku70/80蛋白的作用机制...
全称: Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His Tag) 价格说明 价格:商品在平台的展示标价,具体的成交价格可能因商品参加活动等情况发生变化,也可能随着购买数量不同或所选规格不同而发生变化,如用户与商家线下达成协议,以线下协议的结算价格为准。 特别提示:商品详情页中(含主图)以文字或者...
结论H.pylori感染在体内外能通过改变胃黏膜DNAPKcs和Ku70/Ku80二聚体蛋白的表达水平,影响细胞DNA损伤修复,导致胃 黏膜病变。 【关键词】DNA结合蛋白质类;催化域;蛋白激酶类;纤维蛋白纤维蛋白原降解物;DNA损 伤;螺杆菌,幽门;沙鼠亚科 Effectsof Helicobacterpylori on theexpressionofcatalyticsubunitoftheDNA_dependent...
Rivera-Calzada Angel,Spagnolo Laura,Pearl Laurence H,Llorca Oscar.Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs.EMBO Reports. 2006A. Rivera-Calzada, L. Spagnolo, L.H. Pearl, O. Llorca, Structural model of full-length human Ku70-Ku80 ...
产品名称:Ku70 & Ku80 Heterodimer蛋白 别名: 86 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 2; ATP dependent DNA helicase II 80 kDa subunit; ATP dependent DNA helicase II 86 Kd subunit; ATP dependent DNA helicase II; ATP-dependent DNA helicase 2 subunit 2; ATP-depen...
LRIK interacts with the Ku70–Ku80 heterodimer enhancing the efficiency of NHEJ repairDNAMolecular biologyDespite recent advances in our understanding of the function of long noncoding RNAs (lncRNAs), their roles and functions in DNA repair pathways remain poorly understood. By screening a panel of...
蛋白名称:Ku70 & Ku80 Heterodimer 蛋白,Ku70 & Ku80 Heterodimer protein蛋白表达:Ku70 & Ku80 Heterodimer protein is produced with Baculovirus-Insect Cells.蛋白纯度:Ku70 & Ku80 Heterodimer protein purity > 90 % as determined by SDS-PAGE标签:His Tag蛋白构建:A DNA sequence encoding the XRCC5 (...
Purpose: Both Ku80 and Ku70 are promising drug targets for hepatocellular carcinoma (HCC) and crucial for immune regulation. However, their correlation with HCC immune signatures has not yet been investigated. Therefore, we aimed to investigate the relationship between Ku80, Ku70, an...
DNA—PK亚单位Ku70、Ku80在不同分期乳腺癌中的表达情况
of RNA oligos were synthesized for each Ku70 and Ku80, and the siRNA sequences were shown in Table 1. The HR reporter comprised a target plasmid and a donor plasmid. In the target plasmid, a CMV promoter was used to drive the expression of a deficient EGFP, in which a stop codon...