In H1299 as well as in A549 lung cancer cell lines, biologically, KU60019 combined with VP-16 (one of the TOP2 poisons) synergistically suppressed the growth of cells and survival and triggered a much higher apoptosis rate. In summary, we provide a proof-of-concept strategy that ATM ...
kusnezoffii, has shown efficacy in combating multidrug-resistant cancer in chemotherapy, acting through mechanisms such as apoptosis induction, inhibition of cell proliferation, and anti-inflammatory activities [95]. Additionally, Zhao et al. [122] found that a water decoction of Radix Aconiti ku...
Panobinostat kills bladder cancer cells in the nanomolar range, causes G2/M cell cycle arrest, and causes γH2AX foci increase First, we determined the inhibitory effect of panobinostat (PAN) on growth of RT112, RAD51KD, Ku80KD and NSC cells by clonogenic assay. After 24 h treatment, IC50...
inhibits cancer cell growth, hypaconitine (3), which induces apoptosis, and deoxyaconitine (10), which inhibits cancer cell proliferation [123]. Anti-tumor Malignant tumors are among the most common forms of cancer, characterized by rapid growth, the ability to metastasize to distant tissues, lac...
Breathnach OS, Freidlin B, Conley B, Green MR, Johnson DH, Gandara DR, O'Connell M, Shepherd FA, Johnson BE: Twenty-two years of phase III trials for patients with advanced non-small-cell lung cancer: sobering results. J Clin Oncol. 2001, 19: 1734-1742. CAS PubMed Google Scholar ...
By using MLN4924, an anti-cancer drug in clinical trials that specifically inhibits conjugation of the ubiquitin-like protein, NEDD8, to target proteins, we demonstrate that NEDD8 accumulation at DNA-damage sites is a highly dynamic process. In addition, we show that depleting cells of the ...
Entinostat (SNDX-275) for the treatment of non-small cell lung cancer. Expert Opin. Investig. Drugs 24, 1101–1109 (2015). Article PubMed CAS Google Scholar Simms-Waldrip, T. et al. The aggresome pathway as a target for therapy in hematologic malignancies. Mol. Genet. Metab. 94, 283...
McGee, et al., “A synergistic relationship between TNF-alpha, IL-1 beta, and TGF-beta 1 on IL-6 secretion by the EC-6 intestinal epithelial cell line”, Immunology Sep. 1995;86(1) :6-11. Wu, et al., Transfection of ovarian cancer cells with tumour necrosis factor alpha (TNF-alp...
Anti-Ku antibodies are autoantibodies targeting the Ku protein, which is an 80 and 70 kDa DNA-binding protein involved in the DNA repair pathway for double-strand breaks and preventing telomere shortening [15]. Telomere degradation results in cellular replication arrest and premature cell death. Thi...
Some drugs can inhibit cell mitosis, for instance, the anti-cancer drugs interacting with the tumor cell proliferation and leading to mitosis arrest at a specific phase or cell death eventually. Combining machine learning with microfluidic impedance flow cytometry (IFC) offers a concise way for ...