However, ATM (KU55933) or DNA-PK (NU7441) kinase inhibitors did not block the formation of CJ products or the expression of GFP in Paxx À / À cells, despite the fact that Xlf À / À pre-B cells require both ATM and DNA-PK kinase activity for efficient V(D)J ...
For ATM inhibitor treatments, MEFs were incubated with 10 μM of KU-55933 (Selleck Chemicals, Houston, TX) for 1 hour prior to 4 Gy of irradiation. For Aurora B inhibitor treatments, MEFs were incubated with 20 nM of AZD-1152 and 50 nM ZM447439 (Sigma-Aldrich) for 48 ...