migration, invasion, drug resistance, and sphere formation in breast cancer cells. We report for the first time, a novel function of KRT19 in the NOTCH signaling pathway. Our data show that KRT19 directly interacts with β-catenin/RAC1 complex to regulate the stability and translocation of β-...
KRT19 was knocked down in KTC-1 cells, and the proliferation, migration, and invasion abilities of PTC cells were determined using CCK-8, immunofluorescence labeling, Western blot for EMT-related proteins, scratch assay, and Transwell assay. The role of ERα in relation to KRT19 was ...
We then checked the expression of stemness marker genes (NANOG, OCT4, and SOX2), EMT markers (N-cadherin and E-cadherin), and the tumor suppressor gene P53, using qRT-PCR analysis. The KU-CSLC cells showed a significant upregulation of stemness marker genes (NANOG, OCT4, and SOX2) ...