kras signaling up hallmark -回复 什么是Kras信号通路,并阐述其在癌症发展中的重要性。 Kras信号通路是一种关键的细胞信号传导通路,它在正常细胞生长和分化中发挥着重要的作用。然而,当这一信号通路发生异常时,常常会导致癌症的发展。在这篇文章中,我们将逐步阐述Kras信号通路的相关内容,并探讨其在癌症中的作用。
KRAS 信号通路在多种癌症的发生和发展中发挥着重要作用,如肺癌、结直肠癌和胰腺癌等。KRAS 突变会导致信号通路的持续激活,从而促进细胞的增殖和生存,最终导致肿瘤的发生。因此,研究 KRAS 信号通路对于了解癌症的发生机制和开发新的治疗方法具有重要意义。 【3.KRAS 信号通路的研究进展】 近年来,KRAS 信号通路的研究取...
在人体中,KRAS基因的突变可能导致细胞生长失控,进而引发一系列与肿瘤相关的疾病。因此,深入了解KRAS信号转导机制,对于预防和治疗相关疾病具有重要意义。 首先,KRAS基因编码了一种GTP酶,它通过与相关配体相互作用,将细胞内的信号从一处传递到另一处。这种信号转导过程是细胞内许多重要生理过程的基础,包括细胞生长、分化...
KrasG12Dinduces gallbladder adenoma and Notch plays a key role in Kras-initiated gallbladder tumorigenesis. 展开 关键词: gallbladder tumorigenesis Kras mutation Notch signaling mouse model adenoma DOI: 10.18632/oncoscience.368 年份: 2017 收藏 引用 批量引用 报错 分享 ...
Our findings indicated that synergistic signaling of KRASG12D and TRβPV led to increased MYC expression. Upregulated MYC contributes to the initiation of undifferentiated thyroid cancer, in part, through enhancing TRβPV-mediated repression of the Pax8 expression. Thus, MYC might serve as a ...
KRAS G12V mutation upregulates PD㎜1 expression via TGF│耚/EMT signaling pathway in human non–small cell lung cancerimmunotherapyKRASNSCLCPD‐L1Although clinical data suggest remarkable promise for targeting programmed cell death protein(PD and ligand (PD㎜1) signaling in non﹕mall cell lung ...
Zhu X, Zhao L, Park JW, Willingham MC and Cheng SY. Synergistic signaling of KRAS and thyroid hormone receptor beta mutants promotes undifferentiated thyroid cancer through MYC up-regulation. Neoplasia. 2014; 16:757-769.Zhu X, Zhao L, Park JW, Willingham MC, Cheng S. Synergistic signaling ...
RB loss in conjunction with oncogenic Kras causes perturbations in TGF-β signaling and upregulates AGR2 expressionPancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with a poor prognosis. PDAC is resistant to chemotherapy and even small tumors have the propensity to metastasize. Thus, ...
Eder S, Arndt A, Lamkowski A et al (2017) Baseline MAPK signaling activity confers intrinsic radioresistance to KRAS-mutant colorectal carcinoma cells by rapid upregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K). Cancer Lett 385, 160-167...