Next, to illustrate the concept further, we use three commonly occurring job descriptions: Sales Manager, HR Manager and IT Manager and three KPIs (New customer acquisition, Profitability and People development) to convert KRAs of each of these Job Descriptions to SMART employee goals. Nothing come...
The study outcomes include HR, with corresponding 95% CI and P-values for OS and PFS using Review Manager 5.4 software for the meta-analysis.#The KRAS mutation appears to have a more beneficial impact on OS (HR 0.54 [95% CI: 0.41–0.71];P<0.00001) and PFS (HR 0.63 [95% CI: 0.53...
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The subgroup analysis showed that KRAS-mutant patients have better survival benefits than KRAS-wildtype patients (HR = 0.52, 95%CI: 0.29-0.95; HR = 0.98, 95%CI: 0.29-0.95)[17]. Another phase 3 clinical trial, KEYNOTE-042, investigated the efficacy and safety of monotherapy of ...
(C) Purified recombinant KRAS-G12C protein was incubated with 1 for 2 hr at 10 μM, and the protein-1 mixture was resolved on a 12% SDS-PAGE. (D) Capillary electrophoresis-mass spectrometry (CE-MS analysis) confirms covalent labeling of KRAS-G12C. After incubation of protein with DMSO...
lysis buffer (BioRad, Hercules, CA, USA). Lysate protein concentration was determined with BCA (bicinchoninic acid) method (Thermo Fischer Scientific, Waltham, MA, USA). The beads and detection antibodies were diluted in a ratio of 1:3. For acquiring data, the BioPlex Manager software was ...
We found KIR2DS4 gene was significantly associated with OS (HR 2.27; 95% CI, 1.08–4.77; P = 0.03). In non-functional receptor homozygotes the median OS was 2.6 months longer than in carriers of one copy of full receptor. Multivariate analysis confirmed KIR2DS4 as a favorable ...
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