临床前研究显示,YL-17231 对多种 KRAS 突变类型具有更强的抑制作用,广泛适用于携带 KRAS G12C、G12D、G12V、G13D、G12R、G12A 等突变及 KRAS 野生型扩增的肿瘤,以及对 KRAS G12C 抑制剂产生耐药性的肿瘤。 JAB-23425 JAB-23425 作为广谱 KRAS 抑制剂...
临床前研究显示,YL-17231 对多种 KRAS 突变类型具有更强的抑制作用,广泛适用于携带 KRAS G12C、G12D、G12V、G13D、G12R、G12A 等突变及 KRAS 野生型扩增的肿瘤,以及对 KRAS G12C 抑制剂产生耐药性的肿瘤。 JAB-23425 JAB-23425 作为广谱 KRAS 抑制剂,可同时抑制 KRAS 的活性及非活性状态,并对 HRAS、...
Tregs)高比例浸润密切相关,KRASG12D 突变通过激活下游的 MEK/ERK 通路,促进 ERK 磷酸化,造成白细胞介素 10(interleukin-10,IL-10)和转化生长因子-β(TGF-β)的过表达,使得 Tregs 大量富集,最终导致胰腺癌组织产生免疫抑制。
G12D point mutation negatively correlated with PD-L1 level and secretion of chemokines CXCL10/CXCL11 that led to a decrease in CD8+TILs,which in turn yielded an immunosuppressive TIME.The analysis of cell lines overexpressing classic KRAS substitutions further revealed that KRAS-G12D mutation ...
货号:ABC-KH8069 价格:¥询价 规格: 1 vial 数量:-+ 产品描述 参考文献 资料下载 相关产品 产品描述/Products Description Human KRAS (G12D/+) LIM1215 Cell lineis Heterozygous knockin of KRAS activating mutation (G12D). 资料下载 相关产品
theKras G12D mutationacti- vatedtheMEK/ERKpathway,therebyup-regulatingthelevelsofinterleukin-10(IL-10)andtransforminggrowth factor-β(TGF-β),whichinducedTregconversion.Insummary,Kras G12D mutationplaysacriticalroleinTreg conversionandcontributestoanimmunosuppressivetumourmicroenvironmentinpancreaticcancer.These ...
目前，针对KRAS G12C靶点的研究方兴未艾，而对KRAS G12D等其他靶点的探索以及泛RAS抑制剂的研发也已进入临床开发阶段。MRTX1133是Mirati Therapeutics研发的一款选择性非共价 KRAS G12D 抑制剂，目前已经获得了FDA 批准，获得新药临床试验申请批准，在 2023 年已经开始进入 I/II 期临床阶段。临床前研究结果显示：...
of the inhibitors for KRAS(G12D); and the inhibitors disrupt the KRAS–CRAF interaction. We also observed the inhibition of cancer cell proliferation as well as MAPK signaling by a representative inhibitor (TH-Z835). However, since the inhibition was not fully dependent on KRAS mutation status...
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia 来自 dx.doi.org 喜欢 0 阅读量: 4 作者:Y Xu,H Fang,Y Chen,Y Tang,H Sun,Z Kong,F Yang,R Kirschner-Schwabe,L Zhu,A Toker 摘要: Biological sciences; Biochemistry; Molecular biology ...
化合物 KRAS G12D MUTATION REGULATOR 4 CAS号: 2621927-57-7 英文名: 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[(tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl- ...