CDX(cellline derived xenograft)人胰腺癌细胞系在免疫缺陷鼠的原位移植瘤 将已建立的人胰腺癌细胞系作为移植物,植入免疫缺陷小鼠制作模型,测试药物安全性和有效性,用于药物筛选、药代动力学和药效学评估及毒性检测。由于人胰腺癌细胞系经过人工多代培养纯化,无法保持肿瘤组织的异质...
KPC34 was active against all AML cell lines tested with IC50s in the nanomolar range. Enforced expression of PLC increased response to KPC34 in vivo. In an orthotopic, xenograft model, KPC34 treatment resulted in a significant increase in survival compared to control animals and those treated ...