Writing on the Web is a technology we are just starting to learn to use. While writing for the Web can be seen as formally and functionally close to writing for print, such a perspective deprives it of the opportunities hypermedia environments and its texts open for us to connect, understan...
Neuronal nitric oxide synthase (nNOS) is involved in the regulation of a diverse population of intracellular messenger systems in the brain. In humans, abnormal NOS/nitric oxide metabolism is suggested to contribute to the pathogenesis and pathophysiolog
animals per genotype analyzed in singlet; Mann-Whitney test, not significant) and citrate synthase (CS; samples from four animals per genotype analyzed in singlet; Mann-Whitney test, not significant) in left ventricular cardiac tissue homogenates were non-significantly reduced in the knock-out ...
Considering the data of the follow-up in vivo imaging, we conclude that genetic loss of the astrocyte-specific TRPA1 receptors attenuates the progress of demyelination in the corpus callosum, but these effects can be noticed only at the time of the most intensive pathological changes. The ...
The knockout of Immp2l activity and the treatment with MitoQ each independently reduced the ratio of open-arm entries (genotype main effect: F(1,56) = 8.262, p = 0.006; treatment main effect: F(1,56) = 7.850, p = 0.007; Figure 3E), which indicates increased avoidance of the ...
the disease phenotype in the KO cells as they exhibited impaired calcium recycling and increased irregular beating events, which recapitulates the pro-arrhythmia phenotypes of DD patients. Further mechanistic study confirmed that MM treatment significantly enhanced the autophagic stress in theLAMP2KO CMs,...