Inthout J, Ioannidis JP, Borm GF. The Hartung‐Knapp‐Sidik‐ Jonkman method for random effects meta‐analysis is straightfor- ward and considerably outperforms the standard DerSimonian‐ Laird method. BMC Med Res Methodol. 2014;14:25
The method described by Hartung, Knapp, Sidik and Jonkman (HKSJ) is known to perform better when trials of similar size are combined. However evidence in realistic situations, where one trial might be much larger than the other trials, is lacking. We aimed to evaluate the relative performance...
Using the Hartung–Knapp method in random‐effects meta‐analyses resulted in 34 of 114 nonsignificant meta‐analyses (29.8%). In the full sample ( N = 261), the null effect was included by the 95% PI in 195 (74.7%) and the opposite effect (e.g., hazard ratio 0.5, opposite effect ...