英文标题: Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters 中文标题:Kmt2c或Kmt2d的丢失使尿路上皮细胞易患肿瘤,并将KMT2A-menin重新分配到双峰启动子。 发表日期:13 January 2025 文章类型:Article 所属期刊:Nature Genetics 文章作者:Naita...
Peer review information Nature Genetics thanks Francisco X. Real, Joshua Snyder and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.Additional information Publisher’s note Springer Nature remains neutral with regard to jur...
Nature,2017,546(7659) :554⁃558. DOI: 10. 1038 / nature22965. [11] Pan S,Wu W,Ren F,et al. MiR⁃346⁃5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activa⁃ ting the β⁃catenin signaling pathway[ J] . Life Sci,2020,244 (5...
Journal of Human GeneticsCheon CK, Sohn YB, Ko JM, et al. Identification of KMT2D and KDM6A mutations by exome sequencing in Korean patients with Kabuki syndrome [J]. J Hum Genet, 2014; 59(6): 321-325.Cheon CK, Sohn YB, Ko JM, Lee YJ, Song JS, Moon JW, et al. Identification...
Genome Medicine (2024) 16:136 https://doi.org/10.1186/s13073-024-01401-9 Genome Medicine RESEARCH Open Access Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities Yuka Takemon1,2,3, Erin ...
Unlikehaploinsufficiency in KS1, these MVs likely result in disease through a dominant negative mechanism.doi:10.1038/s41436-019-0743-3Sara CuvertinoVerity HartillAlice ColyerTerence GarnerSiddharth BankaGenetics in Medicine
The diagnosis of CML patients was based in the unexplained persistent leukocytosis, the presence of Ph-chromosome abnormality detected by routine cytogenetics; or the Ph-related molecular BCR–ABL oncogene detected by fluorescent in situ hybridization (FISH) or molecular test. CML patients called IM ...
Although the two phosphorylated tyrosine residues in PPARγ2 are expected to be either directly or indirectly involved in interacting with one or more subunits of MLL3/4 complexes, the identity of the PPARγ2-interacting subunits and the molecular nature of the interaction interface remain to be ...