临床疗效统计发现高KK-LC-1 mRNA表达的患者的OS(overall survival,总生存期)、DFS(disease-free survival,无病生存期)明显短于低KK-LC-1表达的患者(p<0.001),如图3所示。研究人员将KK-LC-1 高表达细胞系MDA-MB-231进行了基因敲除试验,把 MDA-MB-231/ NC(未敲除对照)和MDA-MB-231 / KD(敲除)细胞注射到...
KK-LC-1高表达与癌症患者的不良生存结局有关。 体外研究表明,KK-LC-1沉默可以抑制三阴性乳腺癌症细胞的增殖、侵袭、迁移和愈合能力,提高细胞凋亡率,并将细胞周期阻滞在G0-G1期。 体内研究表明,KK-LC-1沉默可降低裸鼠的肿瘤重量和体积。结果表明,KK-CL-1可通过MAL2/MUC1-C/PI3K/AKT/mTOR通路调控三阴性乳腺...
人癌/睾丸抗原83抗原(KK-LC-1/CT83)检测试剂盒原理:用纯化的抗体包被微孔板,制成固相载体,往包被抗该指标抗体的微孔中依次加入标本或标准品、生物素化的抗该指标抗体、HRP标记的亲和素,经过彻底洗涤后用底物TMB显色。TMB在过氧化物酶的催化下转化成蓝色,并在酸的作用下转化成Z终的黄色。颜色的深浅和样品中的...
英文名字 KK-LC-1 Antibody FITC-Conjugated 供应商 MyBioSource 产品货号 MBS541958 产品报价 ¥询价/0.1mg ¥询价/Null ¥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868...
英文名字 KK-LC-1 Blocking Peptide 供应商 FabGennix 产品货号 P-KKLC1 产品报价 ¥询价/250ug 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。 产品新闻 背景资料 FabGennix可提供的产品包括一抗和二抗、试剂、试剂盒、肽和阳性对照 ...
3、一种kk-lc-1靶向结合蛋白, kk-lc-1靶向结合蛋白是对kk-lc-1蛋白能特异性结合的蛋白,kk-lc-1靶向结合蛋白的蛋白序列如seq id no.2、seq id no.3、seq id no.4、seq id no.5之一所示。 4、优选地,kk-lc-1靶向结合蛋白的氨基酸序列如seq id no.2所示:其中,第30位、第32位、第33位、第35位...
KK-LC-1 functionally regulates the stemness of TNBC ALDH+cells To determine the functional role of KK-LC-1 in the ALDH+cells,KK-LC-1knockout was performed in MDA-MB-231 and MDA-MB-468 cells via CRISPR/Cas9 (Supplementary Fig.1j). The proportions of ALDH+cells were significantly reduced...
ELISA可用于测定抗原,也可用于测定抗体。在这种测定方法中有3种必要的试剂:①固相的抗原或抗体,②酶标记的抗原或抗体,③酶作用的底物。根据试剂的来源和标本的性状以及检测的具备条件,可设计出各种不同类型的检测方法。 一双抗体夹心法 双抗体夹心法是检测抗原常用的方法,操作步骤如下: ⑴将特异性抗体与固相载体连...
(kk-lc-1) in tissues as well as the corresponding antibodies in serum were examined to find biomarkers related to the prognosis of immunotherapy and to explore its mechanism in the development of liver cancer. results kk-lc-1 expression was found to be 34.4% in histopathological specimens from...
and the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC-1) in tissues as well as the corresponding antibodies in serum were examined to find biomarkers related to the prognosis of immunotherapy and to explore its mechanism in the development of liver cancer.#KK-LC-1 expression was fou...