Three-week-old male WBB6F1/J-KitW/KitW-v/J (W/Wv) mice with c-Kit point mutation, KitW-sh/HNihrJaeBsmJ (Wsh/Wsh) mice with an inversion mutation in the regulatory elements upstream of the c-Kit promoter region, and their wild-type controls (WT) were fed either a normal (0.6%...
Thec-Kitloss-of-function mutations in WBB6F1/J-KitW/W-vmice result in low bone mass. However, these mice are sterile and it is unclear whether the observed skeletal phenotype is secondary to a sex hormone deficiency. In contrast, C57BL/6J-KitW-sh/W-sh(Wsh/Wsh) mice, which carry ...
www.nature.com/scientificreports OPEN Disruption of c-Kit Signaling in KitW-sh/W-sh Growing Mice Increases Bone Turnover received: 20 April 2016 accepted: 21 July 2016 Published: 16 August 2016 Sutada Lotinun1,2 & Nateetip Krishnamra3 c-Kit tyrosine kinase receptor has been identified...
We have determined the precise location of the breakpoint of the W(sh) inversion and the endpoints of the W(57) deletion upstream of the Kit transcription start site and examined the effect of these mutations on Kit expression in mast cells and hematopoietic stem cells and lineage progenitors....
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