最近,有研究小组发现,EAE中克隆扩增的CD8+T细胞识别与H2 Db结合的肽,这些肽刺激Ly49+CD8+调节性T细胞并抑制疾病。 在Science期刊中名为KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19的论文确定表达抑制性杀伤细胞免疫球蛋白样受体(KIR)的CD8+T细胞是人类小鼠...
这些研究结果也为理解自身免疫和传染性疾病之间的关系以及开发靶向KIR+CD8+T细胞的潜在疗法以抑制自身免疫性疾病和传染性疾病中不良的自我反应提供了新见解。(生物谷Bioon.com) 参考资料: Jing Li et al.KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Scienc...
他们评估了人类自身免疫性疾病和传染性疾病中KIR+CD8+T细胞的频率,并分析了它们的转录图谱以及T细胞受体(TCR)库。相关研究结果发表在2022年4月15日的Science期刊上,论文标题为“KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19”。 此外,这些作者开发了一种体外...
KIR+CD8+ T cellsLipidsAutoimmunityType 1 diabetesMacronutrientBackground Recent studies have shown that KIR + CD8 + T cells play a role in suppressing autoimmunity by eliminating pathogenic CD4 + T cells. However, their specific role in type 1 diabetes (T1D) remains unclear. Methods In this ...
【Abstract】ObjectiveTo explore the changes of KIR receptor and function of NK cells and CTL cells in patients with acquired hemophagocytic lymphohistiocytosis(HLH).MethodsThe data of CD8+T cell function and KIR receptor and ...
结果发现KIR3DL1和KIR3DL3在CD4+T细胞中表达的可能性比较低,而KIR3DL1在NK细胞中显著富集。在PBMCs和不同组织中,KIR3DL3在γδ T细胞上富集最多,其次是CD8+T细胞。其中,KIR3DL3在消化道IELs中表达的比例最高,平均14%的γδ T表达KIR3DL3。 之前的报道发现KIR可在终末分化的CD8+T细胞表面表达,为了确定不...
在此之前,臧教授团队揭示了KIR3DL3是B7家族成员HHLA2的第二个但具免疫抑制功能的受体,主要表达在CD56dimNK细胞和终末分化效应记忆性CD8+ T细胞表面。其自主开发的抗KIR3DL3单克隆抗体可以阻断HHLA2-KIR3DL3通路并能显著抑制人肿瘤细胞在...
此研究近期在国际免疫学前沿期刊《Frontiers in Immunology》在线发表了题为"KIR3DL1-negative CD8 T cells and KIR3DL1-negative Natural Killer cellscontribute to the advantageous control of early human immunodeficiency virustype 1 infection in HLA-B Bw4homozygous individuals"的研究论著(影响因子5.5分)。
Here, we demonstrate that a population of unconventional CD45RA+, PanKIR+, and/or NKG2A+ virtual memory CD8+ T cells (TVM cells), which confer rapid and robust protective immunity against pathogens, plays an important role in restraining the HIV DNA reservoir in HIV-1-infected patients with...
产品介绍Product Description Clone REA1010 recognizes the human CD158a (KIR2DL1) and CD158h (KIR2DS1) antigens, two members of the killer immunoglobulin-like receptor (KIR) family expressed on CD56dimCD16+natural killer (NK) cells and CD8+T cells. CD158a (KIR2DL1) is involved in the ...