Banke i tradicionalni pružatelji usluga često imaju dodatne troškove koje prebacuju na Vas pomoću marže na valutni tečaj, Naša pametna tehnologija znači da smo mi učinkovitiji - što znači da Vi dobivate odličnu cijenu. Svaki put. Usporedite valutne tečaj...
The first human cases reported to have abnormally low amounts of nuclear p27KIP1 were associated with increased tumor aggressiveness and a relatively poor clinical outcome for breast and colon cancer (Loda et al., 1997). Recent findings from knock-out models also show data supporting the pro-...
Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA, Koff A 1996 Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85:721– 732 18. Nagahama H, Hatakeyama S, Nakayama K, Nagata...
least some CKI members which is evident from the low frequency of gene deletion across different cancer types (Fig.1), it likely represents an adaptive trait increasing survival, especially in stressed conditions. Therefore, there could be a therapeutic opportunity to shift the balance from the tum...
‘sleep’ has a short-voweled subject agreement prefix in its indicative (matrix) form in (6a) but a long-voweled prefix in its subjunctive (embedded) form in (6b).Footnote5For third person subjects, the prefix is ∅- in most cells of the paradigm, while it is alwaysko(ː)- in...
When we projected the Gif lineage scRNA-seq data to the previous UMAP of Pgc+ scRNA-seq, we found that both Gifhigh and Giflow cells from 2 dpi fell into the previously defined injury-responsive chief cell domain (Figure 3J), whereas the Gifhigh cells from the control condition overlapped...
Abbreviations: Skp2, S-phase kinase-associated protein 2Rb, retinoblastomaTNM, tumor, lymph node, metastasisWT, wild typeKO, knockoutMEF, mouse embryonic fibroblastsiRNA, small interfering RNACRD, carbohydrate-recognition-binding domainPremature senescence induced by oncogenic stimuli or tumor suppressor ...
The same pattern was apparent by immunofluorescence staining; while nuclear levels of p27 are low in LNCaP-S14 cells, nuclear SKP2 levels are highly elevated (Figure 1c). Figure 1 Characterization of the LNCaP-S14 ...
and Koeffler, H. P. (1994) Allelotype of acute lymphoblastic leukemia (ALL) identifies sites of tumor suppressor genes. Blood 84 (suppl. 1): 149a Toyoshima, H. and Hunter, T. (1994) p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78: ...
In breast cancer, p27 was shown to suppress cell cycle and cause cell cycle arrest at G1.21 A low level of p27 is often associated with ER- and PR-negative breast cancer, and more likely to have a high-grade tumor.36 p27 belongs to the Cip/Kip family of cyclin-dependent kinase (...