Binding kinetics refers to the study of the rates at which ligands bind to receptors, which is crucial in drug development for understanding the interaction dynamics between molecules over time. AI generated definition based on: Trends in Pharmacological Sciences, 2018 ...
To experimentally characterize the basis of selectivity, we systematically tested a series of 37 concentration patterns, which we call ‘flags’ because each one uses high concentrations in a chequerboard localized somewhere in one of the shapes (three examples are shown in Fig.3b). We did not ...
Based on the fact that in coal flotation the flotation dynamics reflecting the speed of the flotation process, the analysis of the dynamic model is a crucial issue concerning the industrial practice that will occur. The research on flotation dynamics mainly focuses on the changing rule of flotation...
The fundamental discovery in the 1930s1that a protein’s intracellular concentration is based on a continuous interplay between synthesis and degradation resulted in an ever-growing interest in methods to measure the concentration of a given protein as a function of time. Progressively, an array of ...
RNA levels detected at steady state are the consequence of multiple dynamic processes within the cell. In addition to synthesis and decay, transcripts undergo processing. Metabolic tagging with a nucleotide analog is one way of determining the relative c
usually share a common beta-barrel fold, originally found in GFP15. Despite their molecular weight in the range of 30 kDa, which is often larger than their fusion partner, they are often considered bystanders. Multiple examples, however, indicate influences on experimental outcomes16,17,18,19,...
or whole cell approach balances the advantages of more simple systems (avoiding off target binding, receptor dynamics over time, factors such as cellular permeability and levels of native competitor ligands), with the ambition to study the target proteins in a more native context (e.g. within me...
In all of these examples, the reaction outcome is altered by changing the initial excitation mechanism. The ensuing dynamics are allowed to evolve naturally from this point but with only one possible reaction outcome. Here, within an excitation energy window, we keep both the initial conditions ...
The unit of time is normalized with the inverse of the mRNA degradation rate, and therefore time is non-dimensional: it is measured in units of the mRNA half-life (see Figure 2A for mRNA dynamics). All mRNA and protein degradation rates are constants in model 1 with a fixed value of 1...
(Appl Environ Microbiol. 1997 December; 63(12):4657-63) report the fate of exogenously supplied glycine betaine and the dynamics of endogenous osmolytes that were investigated throughout the growth cycle of salt-stressed cultures of strains of Sinorhizobium meliloti, which differ in their ability ...