Northern analysis showed that KIF3C and KIFC2 are expressed mainly in neural tissues, that KIFC4 and KIF22 are expressed primarily in proliferative tissues and cell lines, and that KIFC3 is apparently ubiquitous. To elucidate the organization of genes encoding kinesin-like motors in the mouse ...
The KIF3 motor transports N- cadherin and organizes the developing neuroepithelium. Nat Cell Biol 2005; 7:474-482. 7 Hunter AW, Caplow M, Coy DL, et al. The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends. Mol Cell ...
A database search for potential homologs of the Kin I family in the entire genome sequence (The Sanger Centre, Hixton, UK) revealed that fission yeast possesses two members, which are named Klp5 and Klp6 (kinesin-like protein). Both proteins show 38% identity to human Kin I/MCAK or Xen...
Kif1bα tail, and Kif1c tail over-expression (Fig.3d). Nucleolin, an RNA binding protein, inhibits axonal growth of sensory neurons through localization of importin β1 RNA and is present in axons, potentially playing a role to sense and regulate cell size44. MBNL1 CLIP tags...
We therefore created a screen where each of the DPC compounds was tested for activity in Eg5, CENP-E, MKLP-1, MCAK, and KIF3C kinesins. Within these data, there is a correlation between cellular IC50 and kinesin ATPase inhibition for CENP-E and MKLP-1. A few compounds emerged from ...