Kindlin-2蛋白｜ELISA指标 Kindlin-2蛋白，也被称为FERMT2（Fermitin family member 2），是一种在细胞黏附和信号传导过程中起重要作用的蛋白质。以下是关于Kindlin-2蛋白的详细解析：基本信息 基因名称：FERMT2别名：Kindlin-2、Mitogen-inducible gene 2 protein (MIG-2)、Pleckstrin homology domain-containing family...
Kindlin 2 promotes breast cancer inva- sion via epigenetic silencing of the microRNA200 gene family. Int J Cancer. 2013;133(6):1368-1379.Yu Y, Wu J, Guan L, Qi L, Tang Y, Ma B, Zhan J, Wang Y, Fang W, Zhang H. Kindlin 2 promotes breast cancer invasion via epigenetic silencing...
Oncology Induced gene expression in bladder cancer| Kindlin-2 and Metallothionein-1X THE UNIVERSITY OF NORTH DAKOTA Mary Ann Sens TalaatSherineArsenic and cadmium (Cd) are environmental agents that have been classified as human carcinogens by the International Agency on Research in Cancer (IARC). ...
To do this, we deleted Kindlin-2 expression in β-cells by breeding the floxed Kindlin-2 (Kindlin-2fl/fl) mice, in which exons 5 and 6 of the Kindlin-2 gene are flanked by two loxP sites34, with the RIP-Cre transgenic mice, in which the 668-bp rat insulin II gene promoter (RIP...
1c). Sixteen 8-week-old male K2fl/fl; AggrecanCreERT2 mice were intraperitoneally injected with tamoxifen (TM) (100 mg·kg−1 body weight per day, 5 injections) for conditional deletion of Kindlin-2 gene in aggrecan-expressing chondrocytes (hereinafter referred to as cKO) (Fig. 1c)....
RNA sequencing was used to analyze the differences in gene expression profiles between LCOs co-cultured with fibroblast and paracancerous organoids (POs). Importantly, we have successfully validated the impact of Kindlin-2 on the regulation of MSCs in organoid formation through lentiviral vector-...
While our studies showed that deletion of Kindlin-2 increased OPN secretion, it is important to determine whether hepatocyte-specific deletion of the Osteopontin (SPP1) gene expression can rescue the phenotypes in Kindlin-2 KO mice in future study. Experimental procedures Animal study Generation of ...
The novel focal adhesion gene kindlin-2 promotes the invasion of gastric cancer cells mediated by tumor-associated macrophages Shen Z,Ye Y,Kauttu T et al.The novel focal adhesion gene kindlin-2promotes the invasion of gastric cancer cells mediated bytumor-associated macrophages... Z Shen,YE Yin...
Entrez Gene ID:(Human) 83706 功能 integrin binding 参与通路 leukocyte cell-cell adhesionintegrin-mediated signaling pathwaypositive regulation of cell migrationintegrin activationregulation of cell-cell adhesion mediated by integrinsubstrate adhesion-dependent cell spreadingplatelet aggregation ...
Infantile Malignant Osteopetrosis Resembling Juvenile Myelomonocytic Leukemia in Infants.###A new mutation in the KINDLIN-3 gene ablates integrin-dependent leukocyte, platelet, and osteoclast function in a patient with leukocyte adhesion deficiency-III.###Radiologic resolution of malignant infantile osteopetr...