Furthermore, stroma attachment resulted in shortening of the G1 phase of cell cycle, significant increases cdk2 activity, degradation of cdk inhibitor p27-GST protein, and decrease in levels of p27Kip1 protein. In addition, solid-phase cross-linking of α5 via immobilized antibody also ...
As shown in Table 1, LeKRP1 interacted strongly with CDKA and CYCD3;1. No interaction was detected between LeKRP1 and the other CDKs and cyclins tested. To demonstrate an in vivo interaction between CDKA and LeKRP1, we performed an immunoprecipitation assay, trapping the KRP1-interacting ...
Fig. 1 Domain structure of TEC kinase family members and key interacting partners of Bruton’s tyrosine kinase. a Schematic overview of the protein structure of BTK and other TEC kinase family members. Shown are five different domains, as explained in text, the Y223 autophosphorylation site, the...
antigen tolerance, and immune evasion. In HCC, CCL22, which can induce CCR4+Treg cells migration into the TME, was upregulated under sorafenib administration. Its upregulation was mediated by TNFα-related receptor-interacting serine/threonine-protein kinase 1 (RIPK1)/NF-κB pathway,223and TGF-...
AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells. PLOS ONE 6, e28804 (2011). Article CAS PubMed PubMed Central Google Scholar Marsin, A. S. et al. Phosphorylation and activation of heart PFK-2 by AMPK has...
protein, 47-kDa tail-interacting protein TIP47 (that binds the cytoplasmic domain of cation-dependent and -independent mannose 6-phosphate receptors for their transport from endosomes to the Golgi body), and cargo selection protein; and (3) perilipin-5, also termed lipid storage droplet protein ...
interacting serine/threonine-protein kinase 1 (RIPK1)/NF-κB pathway,223and TGF-β can also upregulate CCL22 through TGF-β-miR-34a-CCL22 axis.224Upregulating T-cell factor 1 (TCF1), programmed cell death protein 1 (PD-1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and ...
Maiti1,3* Open Access Abstract Background: Family members of sucrose non-fermenting 1-related kinase 2 (SnRK2), being plant-specific serine/ threonine protein kinases, constitute the central core of abscisic acid (ABA)-dependent and ABA-independent signaling pathways, and are key regulators of ...
The Cip and Kip family consists of the proteins p21, p27 and p57, encoded by the genes cdkn1a, cdkn1b and cdkn1c, respectively (Sherr and Roberts, 1999). All Cip/Kip proteins may interfere with the activity of all the CDK-cyclin complexes by interacting with both the CDK and cyclin co...
CDKN1C (cyclin-dependent kinase inhibitor 1 C, P57KIP2) is a paternally imprinted gene, located on chromosome 11p.15, that encodes for the CDKN1C protein, an inhibitor of cell cycle progression. From:Endocrinology: Adult and Pediatric (Seventh Edition),2016 ...