Rationale for treating wet AMD in human using an oral pill consisting of a VEGFR/PDGFR inhibitor X-82. Invest. Ophthalmol. Visual Sci. 54, 3272–3272 (2013). Google Scholar US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT02535286 (2017). ...
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res. 64, 5355–5362 (2004). Article CAS PubMed Google Scholar Lee, S. J. & Kavanaugh, A. Adverse reactions to biologic agents: focus on ...
Roniciclib (BAY-1000394, PHA-848125), a pan-CDK inhibitor that induces cell cycle arrest at the G1/S transition, entered clinical evaluation for small cell lung carcinoma and solid tumors. RGB-286638 is another multitargeted kinase inhibitor that entered clinical evaluation for multiple...
Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: Results from a randomised cont... Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). During the clinical development programme, increases...
5b–d). Moreover, we treated M2 macrophages with miR-5106 inhibitor (antagomiR-5106) to suppress the expression of miR-5106 in the cells, and then extract the exosomes from these cells to investigate the effect of M2D-Exos with miR-5106-silence on the osteoblastic differentiation of BMSCs...
Conversely, LY2090314, an ATP-competitive and highly selective GSK3 inhibitor, is currently under clinical evaluation for cancer treatment (clinical trials: NCT01632306 Phase I/II, NCT01287520 Phase I).In vitroandin vivostudies showed that treatment with LY2090314 in PDAC models increased the inhibi...
CID755673, a compound identified and confirmed as a PKD1 inhibitor after interrogation of the PMLSC library, and CID797718, an analog of CID755673 obtained during the synthesis of the latter structure, were synthesized as described in "Methods". Full size image 3,3-Dibromoazepan-2-one (1)....
Data evaluation was carried out using ArrayPro software (Media Cybernetics, Silver Spring, MD, USA). Similar experiments with the kinase dead mutant were performed. Signals with high intensity in the active kinase experiment but low intensity in the kinase dead control were considered as peptide ...
Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis. J. Chem. Inf. Model. 54, 735–743 (2014). Article Google Scholar Pahikkala, T. et al. Toward more realistic drug–target interaction predictions. Brief. Bioinform. 16, 325–337 (...
(Ioflupane I123 SPECT), consistent with 2017 consensus clinical criteria29,30; see also Methods] and receiving cholinesterase inhibitor therapy (>3 months, stable dose >6 weeks). The main objective of this phase 2a study was to evaluate the effects of neflamapimod on the cognitive domains ...