cystic epithelial cell proliferation, and blood-urea nitrogen levels in both thePkd1f/fPkhd1CreandPkd1RC/RCmice. There was a corresponding reduction in ERK, AKT, STAT3, and mTOR activity and expression of proproliferative factors, including Yes-associated protein (YAP), c-Myc, and Cyclin D1....
Reciprocal diurnal changes of phosphoenolpyruvate carboxylase expression and cytosolic pyruvate kinase, citrate synthase and NADP‐isocitrate dehydrogenase... Diurnal changes of transcript levels for key enzymes in nitrate and organic acid metabolism and the accompanying changes of enzyme activities and ...
Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or mutations in their genes, cause cancer and other diseases. Here, we review the remarkable progress made over the past 20 years in improving the potency and specificity of small-molecule inhibitors of...
Lck expression decreased dramatically as hES cells differentiated; Lck transcript and protein levels were lost more rapidly than those of the well-known pluripotency marker Oct4 during EB formation. The observed changes in Lck expression and activity are unique to hES cells as compared to mES cells...
The aim of this study was to evaluate the effect of a chimera consisted of nucleolin specific aptamer (NCL-Apt) and miRNA let-7d on JAK2 expression level and activity in gastric cancer cells. NCL-Apt–miRNA let-7d chimera was prepared by two methods. Gastric cancer (MKN-45) cell line ...
The study aims to evaluate the expression and activity of glycogen synthase kinase 3 isoforms α/β (GSK3α/β) and to assess their oncogenic potential through a correlation with the expression of cyclin D1 and p53 in oral cancer. The expression of total
337–344 Other proteins that can cause cytoplasmic retention of ERK include PEA15, dual-specificity phosphatase 6 (DUSP6), β-arrestins, and Sef.335,345–350 In contrast, expression of nuclear DUSPs 2, 4, and 5 can mediate dephosphorylation and nuclear anchoring of ERK.351–354 ...
Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing in vivo resistance to anthracyclines. While we previously found TP53 mutations in the L2...
α-synuclein PFFs induce both expression and activation of NF-κB signaling elements We next sought to more thoroughly assess the impact of α-synuclein PFFs on NF-κB activation in astrocytes. While BAY blocks NF-κB signaling by inhibiting upstream IKK activity, we next tested whether direct ...
Western blot analysis was done to see the activation and expression levels of Akt, MAPK (mitogen-activated protein kinase) pathways and Caspase-3. Zetasizer was used to measure the particle size along with the surface charge. α-KAMCA showed almost 88% encapsulation efficacy for AZ628 with ...