I actually didn’t fully understand because nobody had actually given me the full information of what I had in a way that I could kind of go, “Well this is what I’ve got [CKD], and this is why I’ve got it.” [The clinicians] they can answer those [kidney health] questions,...
Our kidneys are responsible for cleaning out our blood and regulating the amount of fluid in our bodies; if they aren’t working well enough or if there is just too much gunk to deal with, you can end up with kidney stones or other ailments. Understanding space’s effects on the kidneys...
The effects of obesity on the kidneys are now better, although not fully understood. Obesity impacts the prevalence of renal cancer and renal calculi and influences the technical aspects associated with their treatment. It also impacts the functions of the urinary bladder with higher rates of ...
“Based on this initial proof of principle, we hope that bioengineered kidneys will someday be able to fully replace kidney function just as donor kidneys do,” Ott told NIH Research Matters. His team is now refining the technique and working to create human-sized organs. The researchers used...
the residency and proportion of rMac have not been fully evaluated in human kidneys. Recent single-cell RNA sequencing data suggested that markers such as CD74 and CD81 might characterize human kidney-rMac26. However, these markers are also expressed on other myeloid subsets of that dataset or...
Mechanisms of contrast-induced nephropathy (CIN) are complex and not fully explained. It has been shown that renal blood flow remains 45% below baseline level for at least 4 h following contrast administration[106]. Renal vasoconstriction with medullary hypoxia may be mediated by high osmolality ...
"At Day 10, some cells' descendants were fully healed while others were not," Kumar said. "The cell lineage that healed had switched off SOX9 expression, while the unhealed lineage, in a continuing attempt to fully regenerate, maintained SOX9 activity. It's like a sensor that switches on ...
we confirmed KIT protein expression specifically within ICs of the medulla that coexpressed TMEM213, but not the PC marker AQP2 (Fig.4f, g). This population also showed specific expression ofCALCAthat encodes for calcitonin gene-related peptide (CGRP) that is well-known for its roles in media...
Strikingly, this profibrotic activity was associated with the Wnt but not the TGF-β1 pathway. FSTL1 bound to Wnt ligands and FZD receptors, whereby it increased the presentation of Wnt ligands to FZD receptors to enhance Wnt/β-catenin signaling. Results FSTL1 was expressed in fibroblasts in ...
“So there is no question that this is not just a dehydration injury, there is actual death of the kidney cells that we are seeing.” What’s behind this damage? While running, your body diverts blood from internal organs like your kidneys to your hard-working muscles. In fact,...