Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage ...
Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology ...
Furthermore, renal tubular regeneration occurs in most models of experimental AKI, but the recovery is often incomplete depending on the severity of injury37,38. Kidneys with focal areas that do not repair fully will present tubular decomposition and nephron loss38,39,40. Reduction in renal mass...
The kidney is composed of diverse cell types with distinct subpopulations and single-cell sequencing can dissect cellular heterogeneity at high resolution1. For example, a small subset of cells within the proximal tubule and Bowman’s capsule express vimentin, CD24, and CD1332,3. These cells have...
Emerging evidence demonstrates that Wnt/β-catenin signaling possesses dual roles in promoting repair/regeneration or facilitating progression to CKD after acute kidney injury (AKI), depending on the magnitude and duration of its activation. In this review, we summarize the expression, intracellular ...
Understanding the mechanisms of repair and regeneration of the kidney after injury is of great interest because there are currently no therapies that promo... B Li,A Cohen,TE Hudson,... - 《Circulation》 被引量: 317发表: 2010年 Poor Cell Survival Limits the Beneficial Impact of Mesenchymal ...
In this review, we summarize recent findings on the role of progenitor/stem cells on kidney repair as well as discuss their potential as a therapeutic approach for kidney diseases. 展开 关键词: Animals Humans Stem Cell Transplantation Regeneration Gene Expression Regulation Renal Insufficiency ...
In vivo experiments on animal's stem cells have shown significant improvements in the renal regeneration and functions of organs. Nevertheless more studies show several improvements in the kidney repair due to stem cell regeneration. 展开 DOI: 10.37191/Mapsci-2582-385X-2(4)-038 年份: 2020 ...
After repair was complete, 66.9% of epithelial cells had incorporated BrdU, compared to only 3.5% of cells in the uninjured kidney. Despite this extensive cell proliferation, no dilution of either cell-fate marker was observed after repair. These results indicate that regeneration by surviving ...
(AKI). RTEC senescence inhibits renal regeneration and repair processes and, concurrently, promotes the transition of AKI to chronic kidney disease via the senescence-associated secretory phenotype. The mechanisms underlying cellular senescence are multifaceted and include telomere shortening or damage, DNA...