Prevalence of diminished kidney function in a representative sample of middle and older age adults in the Irish population 来自 NCBI 喜欢 0 阅读量: 43 作者:GM Browne,JA Eustace,AP Fitzgerald,JE Lutomski,IJ Perry 摘要: Background The prevalence of chronic kidney disease (CKD) using available ...
reminiscent of the nephrotoxic effects of aristolochic acids in BEN. It is possible that the increased SBS40b somatic mutation load itself engenders this reduction in renal function. However, studies of other normal tissues suggest that they are generally tolerant of elevated mutation burdens, except...
To inform the development of strategies to monitor and treat new or progressive CKD after ICU discharge, the aims of this project were: (i) to model the change in kidney function for patients discharged alive from hospital after critical illness; (ii) to compare patients diagnosed with and wit...
and CKD (27 vs. 9%), thus hinting at the contribution of cardiorenal communication to kidney and heart function deterioration [85]. The cardiorenal syndrome (CRS) may develop in COVID-19 patients with underlined HF [92,93]. CRS implies that dysfunction in either the heart or the kidney wi...
Women tend to have slower kidney function decline and better controlled risk factors pre-dialysis but the same mortality rates as men once dialysis starts. In the general population, women tend to have higher diet quality scores. Little is known about how sex differences impact diet quality and ...
Cell engineering continues to advance, with developments like the orthogonal IL-2 (ortho IL-2), which selectively stimulates modified IL-2 receptors to maintain function under immunosuppression [115]. Different extracellular binding domains to different members of the TNF-receptor superfamily have also ...
Consistent with our animal data, these results suggest that FGF23 levels rise early in the course of AKI following cardiac surgery, often before major decrements in renal function are detected. Table 5. Baseline characteristics of AKI cardiac surgery cohort Empty CellAKI, N=4Controls, N=10 Age...
110 These groups were well matched in terms of age, sex, CVD risk factors, and renal function (mean eGFR ∼90 ml/min per 1.73 m2), but the poorly controlled group had higher microalbuminuria.110 In adjusted analyses, suboptimal BP control, increasing BP, and worsening eGFR were associated...
Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target ...
At the clinical level, replacement of kidney parenchyma by increasing number and size of cysts with age is a typical feature of ADPKD, eventually leading to ESRD in a majority of patients. Kidney function measurements, such as serum creatinine, estimated glomerular filtration rate (eGFR) and ...