DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We
ARTICLE Received 12 Mar 2015 | Accepted 27 Oct 2015 | Published 21 Jan 2016 DOI: 10.1038/ncomms10023 OPEN Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function Cristian Pattaro et al.# Reduced glomerular filtration rate defines chronic kidney ...
The serum uromodulin level is associated with kidney function. Clin. Chem. Lab. Med. 52, 1755–1761 (2014). CAS PubMed Google Scholar Pruijm, M. et al. Associations of urinary uromodulin with clinical characteristics and markers of tubular function in the general population. Clin. J. ...
Journal names should be abbreviated according to the List of Title Word Abbreviations. Acknowledgements Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise. ...
and the enrichment in antibiotic resistance genes and taxa support the notion that antibiotic exposure (from childhood up to and during stone treatment) corrupts both the urinary and gut microbiota leading to inflammation, loss of beneficial function, and a bloom of uropathogens which may be exacerb...
Organoids are collections of cells in vitro that resemble a bodily organ in structure and function. These next-generation cell-culture systems remain highly accessible to experimental manipulation and analysis but are also sufficiently complex to model tissue-scale development, injury, and disease (Free...
Thus, with minor modifications, the KUPNetViz may evolve to a more general framework, suitable for organ or tissue specific knowledge bases, which at the same time is not as generic as Cytoscape Web itself but includes the basic bundled knowledge to function as an independent biological network ...
contrast media volume and type and renal function pre-intervention. Inevitably, some modifiers exist that cannot be completely eliminated in large multi-treatment network meta-analysis, leading to some inconsistency, indicating a need for careful interpretation of the results [301]. The consistency plot...
In terms of kidney function, while the initial eGFR for GLP-1 RAs users was notably lower, the difference was no longer significant by the D60-90 interval, hinting at a possible stabilization or amelioration in kidney function attributed to GLP-1 RAs therapy (Figure S2). Fig. 1: Patient ...
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