BUNcreatininekidneymicrofluidic paper-based analytical devicesIn this paper, we describe a Microfluidic Paper-based Analytical Devices(渭PADs)for the simultaneous quantification of two important biomarkers of kidney function in blood.This paper provides a simple, disposable, portable, and inexpensive ...
Measurement of urea excretion as a marker of kidney function is less accurate than creatinine but increases earlier in renal disease. Other pathological states may lead to elevated urea excretion: Upper GI bleeding Dehydration Catabolic states High protein dietsRatio of BUN:creatinineProvides...
The following tests can aid in the diagnosis and assessment of AKI: Kidney function studies: Increased levels of blood urea nitrogen (BUN) and serum creatinine are the hallmarks of AKI; the ratio of BUN to creatinine can exceed 20:1 in conditions that favor the enhanced reabsorption of urea,...
CREATININE -Low levels are sometimes seen in kidney damage, protein starvation, liver disease or pregnancy. Elevated levels are sometimes seen in kidney disease due to the kidneys job of excreting creatinine, muscle degeneration, and some drugs involved in impairment of kidney function. ...
However, there was no notable correlation between serum uromodulin concentrations and proteinuria. When comparing the characteristics among histopathological classes, patients in the focal class demonstrated the best kidney function and the highest urinary uromodulin-to-creatinine ratio and serum uromodul...
2a–c). Of note, mice subjected to IRI/CL-NX and mice subjected to U-IRI had equivalent creatinine levels on days 14 and 30, with BUN values that approached equivalence, suggesting nearly complete recovery of filtration function by the previously injured IRI/CL-NX kidneys as compared to the...
More than 800 million people suffer from kidney disease, yet the mechanism of kidney dysfunction is poorly understood. In the present study, we define the genetic association with kidney function in 1.5 million individuals and identify 878 (126 new) loci. We map the genotype effect on the methy...
Similarly, serum creatinine (Scr) is generally considered as an indicator of renal impairment, sensitively reflecting acute kidney injury (Feng et al., 2018). Therefore, as the reliable indicators of kidney function, eGFR, UACR, Scr, and BUN have been widely detected for decades in the ...
The determination of biochemical markers that reflect kidney function, i.e., serum levels of urea and creatinine, tissue levels of neutrophil-gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1), as well as a panel of oxidative-stress-related and inflammatory biomarkers, ...
BUN was significantly elevated on days 3 and 7. On days 7 and 10, serum creatinine was significantly elevated. Trends were not detectable at other time points or in other dose groups. However, those elevations that were detected corresponded temporally with peaks seen in urinary biomarkers (...