degrees of kidney function.Methods This phase 1 open-label study enrolled subjects with normal and severely impaired kidney function, and end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) or hemodialysis/hemodiafiltration (HD/HDF)...
Kidney dialysis is a treatment for people who have poor kidney function, usually as a knock-on effect of diabetes or uncontrolled high blood pressure, or due to inflammation. Dialysis carries out key kidney functions by filtering blood to remove waste, salt and excess water. In 'haemodialysis'...
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Associations between kidney function and dementia risk are inconclusive. Chronic kidney disease (CKD) severity is determined by levels of both estimated glomerular filtration rate (eGFR) and the urine albumin to creatinine ratio (ACR). However, whether there is a graded increase in dementia risk for...
The occurrence of recovery of kidney function after cessation of graft function or prolonged dialysis treatment has been studied retrospectively, and the frequency was found to be roughly 1%, inasmuch as 8 of approximately 750 patients could dispense with dialysis after 10-131 weeks of treatment. Th...
C-reactive protein (CRP), the prototype marker of inflammation, and cardiac hypertrophy are important prognostic indicators in dialysis patients. Residual renal function (RRF) has also been shown to influence survival of peritoneal dialysis (PD) patients. This study examined the relations between infla...
The median previous duration on maintenance dialysis was 4.0 years (interquartile range, 2.0–7.2 years). Overall, 249 participants (36.3%) had known atherosclerotic disease and 290 (42.3%) were taking aspirin. The baseline characteristics and median duration of study treatment were similar across...
"We found that the treatment with methylprednisolone for six to nine months significantly reduced the risk of losing substantial kidney function, kidney failure requiring dialysis or transplantation, or death from kidney disease compared to placebo," said Joint Principal Investigator Vlado Perkovic from ...
Three markers of kidney function were checked: the rate at which kidneys filter blood, called the GFR or glomerular filtration rate; levels of the protein albumin in the urine; and if they were anemic. They also were asked about previously diagnosed heart disease. The odds of having heart ...
Fig. 1: Association between CpG methylation and renal function. The methylation level of each CpG site was tested for its association with baseline eGFR (a–c) and eGFR slope (d–f). The results of all the 434,908 CpG sites analyzed in this study are shown using Manhattan plots (a,d)...