As evidenced by the relatively small effect sizes, the proportion of phenotypic variance of eGFRcrea explained by all new and known loci was 3.22%: 0.81% for the newly uncovered loci and 2.41% for the already known loci. Associations stratified by diabetes and hypertension status The effects of...
11 and 143 .+-. 9 ml/1.73 m2, respectively. The present study demonstrates that kidney size and function are elevated at the onset of insulin-dependent diabetes. Near-normal metabolic control for 8 days induces a reduction but not a complete normalization in kidney function. Apparently, the ...
Almost 6% and 17% of variability in TNFR2 were explained by CKD status and higher cystatin C quartiles, respectively.Conclusions. Biomarkers of inflammation are associated with kidney function and albuminuria. In particular, substantial variability in soluble TNFR2 is explained by CKD and cystatin C...
especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body...
Abstract Importance In observational studies, increased water intake is associated with better kidney function. Objective To determine the effect of coaching to increase water intake on kidney function in adults with chronic kidney disease. Design, Setting, and Participants The CKD WIT (Chronic Kidney ...
A meaningful description of renal tubular function requires an understanding of the nephron's properties as an integrated tissue as well as those of its constituent parts, including the cells and molecules that contribute to its transport functions. ...
Development of a machine learning model for precision prognosis of rapid kidney function decline in people with diabetes and chronic kidney disease Predicting earlier kidney outcomes is crucial in diabetology settings.The XGBoost model enabled precision prognosis of rapid kidney function decline.The mo.....
Another recently studied mode of entry of the virus is through employing the NRP-1 receptor [34]. NRP-1 is a catalytic and signaling protein widely known for its role in cellular signaling and its function as a cell-surface receptor. It was shown to serve as an entry factor and to poten...
methylated sites in whole blood associated with eGFR14. Although this study revealed insights into gene regulatory mechanisms of kidney function, the associated CpGs explained only 1.2% of the eGFR variance. Other previous studies were focused on CKD patients and/or patients with diabetes or patients...
Fig. 2: Age and parameters associated with kidney function are the main drivers of circulating TMAO in BMIS MetaCardis participants. ACoefficients of determination (Explained Variance; EV) of predicted circulating TMAO levels determined by xgboost algorithms after fivefold cross-validation in the left...