and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = ...
Ravera M, Noberasco G, Re M, Filippi A, Gallina AM, Weiss U, et al. Chronic kidney disease and cardiovascular risk in hypertensive type 2 diabetics: a primary care perspective. Ne- phrol Dial Transplant 2009;24:1528-33. DOI: http://dx.doi. org/10.1093/ndt/gfn692...
Table 4. RCTs on Depression Treatments in Kidney Disease TherapyRCTInterventionPatient PopulationFollow-upOutcome Selective serotonin reuptake inhibitor (SSRIs) Hedayati et al, 2017 (JAMA. https://dx.doi.org/10.1001/jama.2017.17131) Sertraline (initial dose 50 mg daily) vs placebo 201 pts with CK...
One of the main causes of CKD is diabetes mellitus (DM), and oxidative stress is essential to the disease's development. It has been demonstrated that the natural antioxidant melatonin reduces inflammation and oxidative damage in renal tissues. Given the lack of robust evidence, this double-...
Diabetic kidney disease (DKD) occurs in ∼40% of patients with diabetes and causes kidney failure, cardiovascular disease, and premature death. We analyzed the response of a murine DKD model to five treatment regimens using single-cell RNA sequencing (scRNA-seq). Our atlas of ∼1 million ...
In this regard, several inbred rat models provide valuable complementary tools to uncover the genetic basis of complex renal disease phenotypes that are related to common forms of CKD. In this review, data obtained in nine experimental rat models, including the Buffalo (BUF), Dahl salt-sensitive...
This study aims to explore and enhance the expression of empathy in telehealth visits (e-empathy) with Black American Chronic Kidney Disease (CKD) patients, focusing on goals of care conversations. It seeks to address the intersection of CKD, telehealth advancements, palliative care discussions, and...
AKI was defined by the change in SCr (pediatric-modified Risk Injury Failure Loss End-Stage Renal Disease [pRIFLE] criteria) or discharge code. Adequate SCr screening was defined as 2 measurements obtained ≤96 hours apart. Administrative data and laboratory values were merged to compare AKI by...
The endogenous repair process can result in recovery after acute kidney injury (AKI) with adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and progressive kidney disease. There is currently limited knowledge a
and Baxter Healthcare Corporation, Exhibit DX 16 to Declaration of Michael J. Abernathy in Support of Defendants' Motion for Partial Summary Judgment of Infringement—Claim Construction Order Dated Nov. 22, 2004. Fresenius USA, Inc. v. Baxter International Inc. and Baxter Healthcare Corporation,...