International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden1. In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are...
Kidney cancer: RCC classification using miRNA signaturesA microRNA (miRNA)-based classification system that can differentiate between types of kidney tumor has been developed by a team in Toronto, Canada.Renal cell carcinoma (RCC) encompasses a number of tumor types, including clear cell RCC, ...
Since both TG2 and GLS1 can similarly function to protect cancer cells, we then proceeded to demonstrate that treatment of a variety of cancer cell types with inhibitors of each of these proteins results in synthetic lethality. The combination doses of the inhibitors induce cell death, while ...
and have an aggressive course.51The mean age ofkidney cancer diagnosisis 40 years, butmetastatic kidney cancercan present in the teens. Other types of kidney cancers also can occur, includingcollecting ductandclear cell cancers.50,52,53Independent of underlying architecture, cells in the kidney ca...
Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation During gastrulation, cell types from all three germ layers are specified and the basic body plan is established 1 . However, molecular analysis of this key ...
This chapter provides an overview of the many cell types, animal models, and in vitro research that have been used in the stem cell–based therapy approaches now being used to treat kidney issues. The findings of the reported human clinical trials are also highlighted, as well as the ...
- 《Cancer Causes & Control》 被引量: 81发表: 2010年 Potential Role of Genetic Markers in the Management of Kidney Cancer Context Kidney cancer is not a single entity but comprises a number of different types of cancer that occur in the kidney including renal cell tumours as t... K ...
Overexpression of FASN, known as a metabolic oncogene, has previously been found in many types of cancer, and the new study showed expression of FASN was decreased in patients with high BMI compared to normal weight patients. Why FASN is downregulated in obese patients isn't yet known, but ...
O. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One 7, e30733 (2012). Article PubMed PubMed Central CAS Google Scholar Jeck, W. R. et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19, ...
aRASSF10 expression is decreased in various kidney cancer types (log2, data Kort, Anova one way) and RASSF10 downregulation was verified inbchromophobe, papillary and clear cell renal carcinoma (log2, data TCGA, Wilcoxon).cThe loss of RASSF10 expression correlated with kidney tumor stage in...