Pembrolizumab (Keytruda) plus chemotherapy as first-line treatment significantly improved overall survival (OS) for patients with metastatic triple-negative breast cancer (TNBC) whose tumors express a certain level of PD-L1, according to results from the KEYNOTE-355 trial. In patients with a PD-L1...
Pediatric members with TMB-H central nervous system cancers; Members who have experienced disease progression while on programmed death receptor-1 (PD-1) or PD-L1 inhibitor therapy (other than when used as second-line or subsequent therapy for metastatic or unresectable melanoma in combination with ...
The data from the abstract of the study at ASCO shows that Keytruda plus chemo improved progression-free survival (PFS) to 9.7 months, compared to 5.6 months for chemo alone, which was a statistically significant improvement. There was a trend towards improved PFS in patients with lo...
Primary efficacy outcome measures were OS as well as progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) using RECIST v1.1, modified to follow a maximum of 10 target lesions and a maximum of five target lesions per organ....
Keytruda monotherapy continued to significantly improve overall and progression-free survival in patients with previously treated, PD-L1–positive advanced non-small cell lung cancer. Keytruda (pembrolizumab) continued to demonstrate a clinically meaningful improvement in overa...
Table 1: Overall Survival of Efti + KEYTRUDA® versus standard-of-care IO, IO-IO, IO-chemo, and IO-IO-chemo therapies for first-line treatment of advanced non-small cell lung cancer patients with PD-L1 TPS ≥1% *NSQ=Non-squamous;SQ=Squamous ...
Patients on pembrolizumab alone had the lowest rates of serious adverse events (AEs) at 16.9%, followed by chemotherapy alone (69.3%), and pembrolizumab plus chemotherapy (73.2%). The most common AEs included nausea and fatigue. Overall, 22% of patients experienced immune-related toxicities, Tabe...