最主要的诱因是 吸烟和酗酒,另外就是特定的 HPV 感染。预计 2018 年全球新诊断头 颈部肿瘤人数 83.5 万,死亡 43.1 万。在美国 2017 年新诊断 6.3 万例。目前的一线标准治疗是 EXTREME 方案:包括西妥昔单抗+铂类 (卡铂或顺铂)+5-FU。目前 nivo 和 pembro 已经获批二线。 关于试验设计 KEYNOTE-048 是一项...
KEYNOTE-048 是一项随机、开放标签的三期研究,共入组 882 例初治的 r/m HNSCC 患者,1:1:1 随机分配到帕博利珠单抗单药组(P 组,301 例,帕博利珠单抗 200 mgQ3W,共 35 周期),帕博利珠单抗联合化疗组(P+C 组,281 例,帕博利珠单抗 200 mgQ3W,35 周期+6 周期化疗 (顺铂 100 mg/m2 或卡铂 AUC5Q3W+...
此外,该疗法在不同亚组中观察到的抗肿瘤活性基本一致。具体来说,PD-L1CPS小于1的患者、HPV阳性口咽肿瘤患者和HPV阴性口咽肿瘤患者的确诊ORR分别为65%(95%CI,40.8%-84.6%)、65%(95%CI,42.7%-83.6%)和50%(95%CI,28.2%-71.8%)。确诊为CR的患者(49人)的中位反应时间(TTR)为1.5个月(1.1-6.8个月)。 此...
There are several factors that greatly increase the risk of developing head and neck cancer, including tobacco and alcohol use and human papillomavirus (HPV). It is estimated there were more than 930,000 new cases of head and neck cancer diagnosed and over 4...
squamous cells that make up the thin surface layer of the structures in the head and neck. The leading modifiable risk factors for head and neck cancer include tobacco and heavy alcohol use. Other risk factors include infection with certain types of HPV, also called human papillomaviruses. World...
Subgroup analysis: a group of persons in a trial identified by a specific trait, such as gender, race or HPV status, that is studied in order to determine if people with that trait are affected by the treatment Systemic therapy: treatment using substances that travel through the bloodstream, ...
KEYNOTE-048 是一项随机、开放标签的三期研究,共入组 882 例初治的 r/m HNSCC 患者,1:1:1 随机分配到帕博利珠单抗单药组(P 组,301 例,帕博利珠单抗 200 mgQ3W,共 35 周期),帕博利珠单抗联合化疗组(P+C 组,281 例,帕博利珠单抗 200 mgQ3W,35 周期+6 周期化疗 (顺铂 100 mg/m2 或卡铂 AUC5Q3W+...