especially for genes involved in specific key developmental phases.Here we generated RNA sequencing libraries spanning 10 key stages across the entirety of anther development in maize(Zea mays).Global transcriptome analyses revealed distinct phases of cell division and expansion,meiosis,pollen maturation,...
then is punctuated by two sharp jumps in activity during the earliest meiotic stages. More generally, the results also demonstrate how new light can be shed on old, previously examined biological processes—such as meiosis—by bringing
BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair Abstract As a key tumor suppressor in several cancers, BRCA1 is required for the maintenance of genomic stability. Extensive studies have revealed multiple functions of BRCA1 that contribute to its...
In conclusion, the synchronized meiosis analysis revealed that Fbxo47−⁄− spermatocytes experienced delays at the leptotene and zygotene stages due to defective DSB repair. Fbxo47−⁄− spermatocytes were arrested at the pachytene-like stage with centromere pairing defects, exhibiting premat...
(b) Immunohistochemical staining of MCL-1 (brown) in 3-week ovarian sections of wild-type mouse ovaries, counterstained with hematoxylin (blue). PMF oocytes (arrows), PF (PF) and PA follicles (arrowheads), and oocytes undergoing early stages of atresia (red arrowhead). At least three ...
From the transcriptome data, we determined that the number of expressed genes gradually increases from the AP to the TP stages (Figure 1D). This window represents the development and maturation of stamens and pistils after spikelet primordium differentiation, and the completion of meiosis. The AP...
In our study, CCNB1 expression data was obtained through ‘Expression Analysis’ module for the contrast of promoter methylation and gene overall expression level. Further stratified analysis based on gender, age, cancer stages, and histology was also conducted. Additionally, GEPIA2 (http://gepia2...
as primordial germ cells (PGCs), undergo extensive epigenetic reprogramming before progressing to meiosis. The onset of embryonic development relies on fundamental interactions between the sperm and oocytes [48]. Prior to this interaction, the sperm acrosome undergoes a series of transformations essential...
securin. In the final stages ofegg developmentjust before ovulation, it undergoes two specialised cell divisions known as meiosis I and meiosis II. Securin is important for both divisions but in old eggs, it appears that there is insufficient securin remaining to ensure meiosis II takes place ...
and in various fetal tissues [13], indicating a role in meiosis during oogenesis [13,44,54], and early stages of preimplantation development [44] (Table1). Significant levels of BORIS were also found in normal human skin and freshly isolated whole dermis, epidermis, or disaggregated primary ...