To better understand the functional state of NK cells, we used Monocle 2 to determine their developmental trajectory. Pseudo-time analysis showed that NK cells were divided into different stages on the time trajectory (Fig. 6C), that is, different functional states. ResponseScore grouping can ...
Senescence is the gradual deterioration of bodily function that can occur at either the cellular or organismal level. Cellular senescence, or replicative senescence, is characterized by halted mitosis of diploid cells. Meanwhile, organismal senescence is characterized by a reduced stress response and incr...
As you’ll see in the next section, mitosis and meiosis have many differences, but they follow the same general pattern to complete the cell division process. The biggest similarity between the two is that they both produce new cells.While the cells they create have some key differences, the...
Recent research has suggested that the DDR functions as a checkpoint for tumor growth, requiring early malignant lesions to inactivate p53 or other DDR components to advance to more aggressive stages [35]. In glioblastoma patients, copy number loss of the genes encoding the ATM/Chk2 and ATR/...
the cellular or organismal level. Cellular senescence, or replicative senescence, is characterized by halted mitosis of diploid cells. Meanwhile, organismal senescence is characterized by a reduced stress response and increased homeostatic imbalance, resulting in a loss of normal functions in organisms [...
Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and immunosuppression. However, the reciprocal mechanisms by...
DNA Replication, Binary Fission, and Mitosis Overview 53個詞語 jonj748534預覽 Bio: Chapter 8 58個詞語 joshua_a_minor預覽 AP Bio Chap 6 61個詞語 a_murray26預覽 CH 4-8 Quiz 148個詞語 emmaslusher預覽 Stages of Meiosis 15個詞語 maya_beesley預覽 Porters test 62個詞語 rah_hebert10預覽 AP BIO...
Serous ovarian carcinomas (SCA) are the most common and most aggressive ovarian carcinoma subtype which etiology remains unclear. To investigate the prospective role of mRNAs in the tumorigenesis and progression of SCA, the aberrantly expressed mRNAs wer
The target substrates were phosphorylated by the CCNB1-CDK1 complex, which leads to cell cycle progression. Many important steps in mitosis will be initiated by the activated CCNB1-CDK1 complex, including condensation of chromosomes, assembly of spindle pole, and breakdown of nuclear envelope [27...
Gene expression is the process by which genetic information is transferred from DNA to proteins through transcription and translation. The precise control of gene expression in all cells, i.e. the final formation of proteins, is necessary for the functioning of the organism. Therefore, changes in...