Glycolysis plays a central role in the metabolic network of cancer cells. Cancer cells produce energy and substances through glycolysis, and their metabolic product, lactic acid, affects the tumor microenvironment (TME), leading to immune suppression, among other effects. Inhibition of glycolysis can ...
商品品牌:Gibco™ Description Sodium pyruvate is commonly added to cell culture media as a carbon source in addition to glucose. Since cells make sodium pyruvate as an intermediate metabolite in the glycolysis pathway, it is not a required supplement for all cell cultures. However, if cells have...
A third site of control of glycolysis is the irreversible formation of pyruvate catalyzed by the enzyme pyruvate kinase (PK). In the reverse direction, two enzymatic reactions operate. Pyruvate carboxylase (PC) first catalyzes the carboxylation of pyruvate to oxaloacetate (OAA), and the OAA is th...
By promoting glycolysis (Ruminot et al., 2011), maintaining intracellular Na+ levels, and providing feedback acidification of the interstitial space, astrocytes dampen neuronal activity. The finding that pHo decreases from 7.4 in anesthesia to 7.25 during quiet wakefulness (Ding et al., 2016), ...
found that xanthohumol exerted a significant antitumor effect on CRC cells by downregulating HK2 expression and suppressing glycolysis. Besides, it could promote the release of Cyt-C to activate apoptosis.125 Lycorine, as a natural compound isolated from the Amaryllidaceae plant, was shown to induce ...
As a result, a total of 123 proteins, 70 upregulation proteins and 53 downregulation proteins, were identified as DAPs which may be related with the differentiation process of goat intramuscular adipocytes. Furthermore, the cholesterol metabolism pathway, glucagon signaling pathway and glycolysis / ...
[179] and glycolysis [180]. In each case, the textile is first cut into pieces and then submerged in a chemical solution for high-temperature depolymerization with specific catalysts [181]. Additives and dyes dissolved in the solution must be removed and disposed of properly, and then the ...
We find that 30% of transcribed genes are translationally regulated, including key gene sets (neurodevelopment, transcription and translation factors, and glycolysis). Approximately 35% of abundant intergenic long noncoding RNAs (lncRNAs) are ribosome engaged. Neurons translate mRNAs more efficiently and...
PKM encodes pyruvate kinase enzyme that is one of the key enzymes of glycolysis [27]. The upregulation of PKM2 in diabetes was shown to protect against the progression of diabetic nephropathy and mitochondrial dysfunction by reducing the production of toxic glucose metabolites [88]. In contrast ...
(HK2) is overexpressed in human cancers, accelerating glucose uptake and forming the HK2-VDAC complex to generate apoptosis resistance.124Liu et al. found that xanthohumol exerted a significant antitumor effect on CRC cells by downregulating HK2 expression and suppressing glycolysis. Besides, it could...