Its unique structure allows it to act as a spring-like molecule, assisting in the regulation of muscle contraction and relaxation. As muscle fibers shorten during contraction, titin stores energy, which is then released during relaxation, contributing to the smooth and controlled...
Most pathogenic variants of SYNGAP1 are predicted to result in haploinsufficiency. However, some affected individuals carry missense mutations in its calcium/lipid binding (C2) and GAP domains, suggesting that many clinical features result from loss of functions carried out by these domains. To test...
Silencing of PW1 in a polyclonal population of adult mouse MABs interfered with the two main features of these cells: shPW1 AdmMABs showed not to be able to differentiate in skeletal muscle and to cross the vessel wall. These results were also verified in different clones of embryonic and ...
Overview: Importance of Biological Membranes in Disease Processes (S.T.Ohnishi). Membrane Transport and membrane Receptors: Calcium Ions and Calcium Channel Blockers (J. Ferrante and D.J. Triggle). Features of the ATP-Sensitive Potassium Channel in Vascular Smooth Muscles (K. Kitamura, S. ...
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Traction epiphyses are nonarticular; they serve as sites of origin or insertion for muscles, such as the greater and lesser trochanters, the tuberosities of the proximal humerus, the epicondyles of the distal humerus, and the tibial tubercle. The concept of the growth plate oversimplifies the...
LPL activity increases in white adipose tissue (WAT) after eating but decreases in muscles. On the other hand, during fasting, LPL activity decreases in WAT but increases in muscles. However, a significant portion of the mechanism governing tissue-specific LPL activity throughout the fed-fast ...
It is RHAMM that regulates cellular responses to growth factors and plays a role in cell migration, particularly for fibroblasts and smooth cells [30,60]. The interactions of HA-RHAMM play important roles in inflammation and tissue repair [1,26], triggering a variety of signalling pathways, ...
A more common example of this process of atrophy is seen when muscles are not used for a period of time (e.g. when a limb is immobilised in plaster to allow healing of a broken bone). The muscles in that area become visibly smaller and, when the plaster is removed, muscle strength ...
The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on ne