Multiple proteins can simultaneously bind to a single RNA molecule. The particular combination of proteins dictates the fate of that mRNA. Networks of protein-RNA interactions, referred to as "protein-RNA networks", underlie fundamental cellular processes and have well-established connections to disease...
While certain sequence features of proteins, such as modular interacting domain and low complexity sequences, that promote LLPS have been well studied, how small subset of amino acids are quantitatively encoded to contribute to phase separation remains largely unknown11,12,13, which limits the ...
and blood flow. Vascular and interstitial cardiac cells exhibit cell cycle arrest, inflammation activation, p16INK4A expression, telomere shortening, and acquisition of SASP during senescence [22]. Meanwhile, the accumulation of senescent cells and calcification are features of atherosclerotic plaques in ...
The show features pairs of adult identical twins who participated in a study published in November 2023. For eight weeks, everyone in the study ate a diet rich in fruits, vegetables, whole grains, and legumes and low in sug...
II. Immunocytochemistry of peptides, calcium-binding proteins, DARPP-32, an... and intermediate fields of the neonate monkey entorhinal cortex, a particular subset of pyramidal-shaped neurons: located in layer III, they were characterize... B Berger,C Alvarez - 《Hippocampus》 被引量: 225发表...
They used nanofabrication used in semiconductor device processing to create a biomimetic surface that simulates the key features of the antigen-presenting cell (APC). The immune process involves an intricate choreography of receptor proteins and their ligands at or near the surface of the T-cell an...
2020). And, ECM proteins mediate adhesion or attachment of muscle stem cells, meaning the ECM mediates satellite cell responses to mechanical activity and tissue perturbation (Li et al. 2018; Moyle et al. 2020). The ECM forms a complex three-dimensional meshwork of proteins that surrounds ...
The Search Tool for the Retrieval of Interacting Genes/Proteins (STRING:http://string-db.org/) is online biological database and website designed to evaluate PPI information [16] Proteins associated with DEGs were selected based on information in the STRING database (PPI score >0.7), and then...
30. The ECFP generation involves three stages: (1) initial assignment of integer identifier to each atom; (2) iterative update of each atom identifier to reflect its neighbors and identify duplicated structural features; and (3) duplicate identifier removal, reducing multiple occurrences of the ...
Identifying the genes that regulate the TS network is one of the main challenges in understanding its aetiology. Here, we studied the regulatory network from manually curated genes reported in the literature and identified essential proteins involved in TS. The power-law distribution analysis showed ...