Multiple proteins can simultaneously bind to a single RNA molecule. The particular combination of proteins dictates the fate of that mRNA. Networks of protein-RNA interactions, referred to as "protein-RNA networks", underlie fundamental cellular processes and have well-established connections to disease...
Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2 Clement Verkest, Irina Schaefer, Timo A. Nees, Na Wang, Juri M. Jegelka, Francisco J. Taberner & Stefan G. Lechner Nature Communications volume 13, Article number: 1365 (202...
The show features pairs of adult identical twins who participated in a study published in November 2023. For eight weeks, everyone in the study ate a diet rich in fruits, vegetables, whole grains, and legumes and low in sug...
We describe here a high-resolution crystal structure of “Man9-V3” bound with the single chain variable fragment (scFv) of the N332-glycan dependent bnAb, DH270.6. We have also determined a structure of the Fab of a clonally related member of this lineage, DH270.3 (11.8% mutated nucleoti...
Proximity ligation assays (PLAs) can detect proteins in situ that are ≤40 nm apart and thus likely to interact with each other, either directly or by forming a complex with other proteins. Using a PLA designed to detect interactions between tau and PTEN, we saw a strong signal in primary...
Cell death modalities, their features and common detection methods. 2. Non-programmed cell death Non-programmed necrosis Non-programmed necrosis is stimulated by a number of external factors, e.g., infection, toxins and physical injury, which lead to morphological alterations, such as cytoplasmic sw...
The wheels of the car are the integrins, which are transmembrane proteins that allow cell–cell and cell–extracellular matrix interaction during cell migration. The petrol in the car is the ATP that provides the energy for cell migration. The car engine is the actin cytoskeleton that forms the...
In L. monocytogenes, as in other bacterial pathogens, it has been shown that swimming ability19 and the Agr quorum sensing-like system are important at the early stages of biofilm formation, with the latter being involved in the regulation of proteins relevant for adhesion to surfaces and/or ...
Identification of Proteins Interacting with Human SP110 During the Process of Viral Infections Human SP110 plays an important role in resisting intracellular pathogens, and hence has become an important drug target for preventing intracellular pathog... KC Chou,JF Wang,Y Wang,... - 《Medicinal Che...
These proteins are involved in immune modulation and cancer immunity. We show that P-selectin mediates microglia-enhanced GB proliferation and invasion by altering microglia/macrophages activation state. We demonstrate these findings by pharmacological and molecular inhibition of P-selectin which leads to ...