Notably, by 1945, the surgical literature had identified the features of muscle regeneration induced by loss of vascular supply, including the “myotube stage” discussed by Le Gros Clark and Blomfield (1945) and took note of previous studies of contractures after traumatic wartime injuries or vas...
Fig. 12.1 Lateral and axial views of the female pelvis. (a) Diagram illustrating the position of the pelvic organs, the peritoneal pouches, the major suspensory ligaments, and the pelvic floor muscles for orientation and reporting. (b) Cross section through the female pelvis to display the rela...
Moreover, experimentally-reduced flux through single reactions does not reproduce key features of IR-linked metabolism. However, dual knockdowns of pyruvate dehydrogenase (PDH), in combination with reduced lipid uptake or lipid/amino acid oxidation (ETFDH), does reduce ATP synthesis, TCA cycle flux...
This scenario would account for fibrosis that starts in the endocardium (where wall stress is highest) but not at the mid-myocardium as is seen in the cardiac involvement in Fabry disease[50]. Thus, other unknown factors are contributing to hypertrophy and fibrosis. The relative contribution of...
of reflex-mediated effects (Kaufman and Forster1996; Kaufman et al.1983) that interact with central perceptual features of “effortful” work (Mitchell et al.1983). Of these factors, the potential role of cardiac function in exercise blood pressure regulation is often overlooked. For example, ...
Sodium/calcium exchange in cardiac, smooth and skeletal muscles: key to the control of contractility. Curr. Top. Membr. Transp. 34:289-330, 1989.Blaustein MP (1989) Sodium-calcium exchange in cardiac, smooth, and skeletal muscles: key to control of contractility. In: Hoffman JF, Giebish ...
A more common example of this process of atrophy is seen when muscles are not used for a period of time (e.g. when a limb is immobilised in plaster to allow healing of a broken bone). The muscles in that area become visibly smaller and, when the plaster is removed, muscle strength ...
The contraction and relaxation of cardiac muscles causes blood to flow in and out of the heart. During each cardiac cycle, a group of tissue in the heart called the sino atrial node (a.k.a., the pacemaker of heart) generates electrical impulses that spread all through the heart and cause...
Such pathologies include genetic/metabolic diseases, erythroid tissue homeostatic disorders such as sickle cell anemia (SCA), thalassemia, other anemias, degenerative disorders of bones, skeletal muscles, cartilage-forming tissue and vascular bed and some forms of cancer, all considered as severe unmet...
Figure 3. Confocal fluorescence intensity analysis of junctional nAChRs in SOL and EDL muscles of Bion-M1 flown (BF) vs. two Bion-M1 ground controls mice (FC, BG). A significant decrease in pixel fluorescence intensity was measured in SOL muscle (upper panel) of Bion-M1 flown mice (BF vs...