At the cellular level, different types of cellular senescence are the basis of cardiac senescence. The replicative capacity of cells is limited, indicating that aging occurs at the cellular level, namely, as “cellular senescence”. Senescent cells exhibit cell cycle arrest, which initiates tissue r...
By 1949, Newman (1949) recognized “the importance of an accurate evaluation of a disability”, since “muscle strength, to a great extent, governs the amount of function of a part.” While this might seem obvious now, many early measurement devices were not standardized and their use was n...
Moreover, experimentally-reduced flux through single reactions does not reproduce key features of IR-linked metabolism. However, dual knockdowns of pyruvate dehydrogenase (PDH), in combination with reduced lipid uptake or lipid/amino acid oxidation (ETFDH), does reduce ATP synthesis, TCA cycle flux...
At the cellular level, different types of cellular senescence are the basis of cardiac senescence. The replicative capacity of cells is limited, indicating that aging occurs at the cellular level, namely, as “cellular senescence”. Senescent cells exhibit cell cycle arrest, which initiates tissue r...
Cortex: The ovarian cortex contains follicles at various stages of maturity and also the corpora lutea. Medulla: The ovarian medulla is composed of connective tissue, smooth muscle cells, and elastic fibers and is traversed by blood vessels, lymphatics, and nerves. The zonal anatomy of the ovary...
SMYD proteins: key regulators in skeletal and cardiac muscle development and function. Anat Rec (Hoboken). 2014; 297: 1650-1662.Du SJ, Tan X, Zhang J. SMYD proteins: key regulators in skeletal and cardiac muscle development and function. Anat Rec. (2015) 297:1650-62. doi: 10.1002/ar....
• Cardiac muscle has many structural and functional characteristics intermediate between those of skeletal and smooth muscle and provides for the continuous rhythmic contractility of the heart. Although striated in appearance, cardiac muscle is readily distinguishable from skeletal muscle and should not ...
Functional annotation of Gene Ontology (GO) terms was initially performed to identify the biological meaning and systematic features of the candidate genes using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) and KEGG Orthology-Based Annotation System (KOBAS). The gene ont...
Rationally, ideal in vitro models should closely resemble human in vivo cardiac features, replicating the disease phenotype and its underlying causality to enable clinical translation. However, the degree of in vivo resemblance of an in vitro model is typically proportional to the complexity of its ...
2.5. Consensus Clustering Analysis of the Model Genes Consensus clustering was conducted on the LumA samples based on the expression of genes in the prognostic risk model to explore the different features of function. According to the cumulative distribution function curve (Figure 5A) and the delta...