RXI-109 reduces a key component of dermal scarring, connective tissue growth factor mRNA, in a multidose phase 1 clinical trialBackground: RXI-109 is being developed to target and reduce CTGF, a key regulator of the dermal scarring pathway, as a means to reduce hypertrophic scarring and ...
IntroductionEfficient intestinal peristalsis is a function of intact enteric nervous system, muscle, and connective muscularis propria tissue. Malfunction of any component results in impaired peristalsis. Hirschsprung disease (HD) as prototypic enteric neural migration disorder is increasingly well characterized...
A component in the formation of collagen—a protein used to build bone, cartilage, muscle, and connective tissue—vitamin C helps maintain healthy blood vessels, heal wounds, absorb iron, and support immune function. Where can my child get it? Breast milk, toddler milk drinks, fruit (citrus ...
Elastin is a major component in large arteries where it forms parallel lamellae, regularly distributed between the muscle layers. Variations in the amount and composition of ground substance components such as proteoglycans and hyaluronate also contribute to the physical and metabolic properties of the ...
But with consistent use, these connections can strengthen over time, Rosengart says. To restore the inhibited or fortify the well-functioning neural circuits, you’ll need to tap into another key component of the mind-body connection: an internal attentional focus. ...
In today’s episode, you’ll gain a fresh perspective on generative AI through the analogy of a car engine. You’ll discover why viewing AI as just one component of a larger system is crucial for setting realistic expectations. You’ll learn how this analogy can help you communicate the c...
c The second vimentin element interacts with actin filaments and is involved in the transmission of contractility-based tensile forces to the matrix. Full size image Modeling the active cellular contraction The first component of the model is myosin motors which generate internal contractility (Fig. ...
Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whol...
CyPA is encoded by the peptidyl prolyl isomerase A (PPIA) gene, and regulatory PPIA polymorphisms were found to be a component of genetic susceptibility to HIV-1 infection or disease progression.47 In addition, analysis of sera from HIV-1-infected individuals has revealed higher protein ...
Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, a