CONSTITUTION:A Grignard reagent (G) of the formula R<1>MgX is reacted with a carboxylic acid halide of the formula R<2>COX (R<1> and R<2> are the same or different organic groups selected from straight or branched chain alkyl, cycloalkyl, aryl, and aralkyl groups, and may have a...
5.Carboxylic acids react with Grignard reagents and organolithiums to formketones. 6.Ketonescan be reduced at neutral pH using the thioketal method. 7.The simpleketonesinclude aromatic, heteroaromatic, and alkenyl ketones. 8.The simple ketones include aromatic, heteroaromatic, and alkenylketones. ...
Those 5-ones with a 4,4-disubstituent undergo addition of the Grignard reagent to give a 5-ol (Scheme 63) 〈73BSF3079〉. Sign in to download full-size image Scheme 63. The hydrogenation of N-substituted isoxazolin-5-one ethyl esters produced aminomethylenemalonates 〈74G715〉, while ...
generation of alkyl enol ethers regioselectively from benzotriazole derivates such as103<1995JOC7605>. Reaction of compound104with Grignard reagents leads to displacement of the benzotriazole group to give ethyl enol ethers that react with brominein situto give internally brominated ketones (Scheme 23)...
With sodium tetrahydroborate; nickel(II) chloride hexahydrate; hydrogen In methanol at 0 - 30℃; under 760.051 Torr; Reagent/catalyst; Solvent; Temperature; Time; Reflux; Inert atmosphere; A 1%B 98% With sodium tetrahydroborate; nickel dichloride In methanol A 38%B 61% With methanol; formic ac...
a119.0 g of cyclopentyl bromide and 19.4 g of magnesium are reacted in ether or THF to give a cyclopentyl Grignard reagent. The best yields are obtained if 镁119.0 g cyclopentyl溴化物和19.4 g在以太或THF起反应给cyclopentyl Grignard试剂。 最佳的出产量得到,如果 [translate] acontaining some ...
The novel process for preparation of the diarylmethanol 3 comprises reacting an N-carboxyanhydride 2 with an aryl Grignard reagent: ##STR9## wherein n is 1 or 2; R1and R2independently represent hydrogen, C1-3 alkyl or joined together represent with the carbons to which they are attached a...
organo‐silicon compounds, heterocyclic O,N,S derivativesThe silyl-protected iodohexenol (Ia) is converted into the nitrile (Ib) which reacts with the methyl Grignard reagent (III) to form the protected octenolon (IV).doi:10.1002/chin.198822177...
PREPARATION:A phenothiazinoalkanoic acid ester having 1'-carboxyl-1'-Y-ethyl group in the 10 position of the phenothiazine ring of formula II (PN- is phenothiazine residue connecting to the N atom in the 10 position) is made to react with a Grignard reagent of 3-dialkylamino-propyl halide...
PREPARATION:A phenothiazinoalkanoic acid ester having 1'-carboxyl-1'-Y-ethyl group in the 10 position of the phenothiazine ring of formula II (PN- is phenothiazine residue connecting to the N atom in the 10 position) is made to react with a Grignard reagent of 3-dialkylamino-propyl halide...