Ketone bodies are synthesized in the liver and kidney cortex and are used by most other tissues as an important source of energy.doi:DOI: 10.1016/B0-12-475570-4/01447-5Oliver E. OwenRichard W. HansonEncyclopedia of Endocrine Diseases
Ketone bodiesconsist of acetoacetate, D-β-hydroxybutyrate (D-3-hydroxybutyrate), and acetone. They aresynthesized in liver mitochondria. The overall steps involved in the formation ofketone bodiesinclude the mobilization of fatty acids bylipolysisfrom adipose tissuetriacylglycerolby hormone-sensitivetriacylg...
in what part of the cell does the synthesis of ketone bodies occur? - matrix why are ketone bodies synthesized in the matrix? (1) - because the starting material is excess Acetyl CoA from beta oxidation which occurs in the matrix
8.Instead of being fueled by sugar, as it usually is, it begins to metabolize fat-derived molecules calledketonebodies, hence the term ketogenic diet. 由脂肪转变而来的分子—酮体,取代了通常的糖,开始为大脑的新陈代谢功能。因此术语称之为生酮饮食。
These results suggest that malignant hepatocytes, as a consequence of their production and release of large quantities of cholesterol, derive metabolic advantage over neighboring normal hepatocytes by being able to consume ketone bodies synthesized by normal cells in response to the elevated cholesterol ...
Ketone Bodies: Ketone bodies are a metabolite used in the body when glucose is low in concentration. Ketone bodies can be used when the body is under fasting conditions, after strenuous exercise, or with health conditions like diabetes. Answer...
The myocardium—especially in the failing heart [2, 4]— utilizes ketone bodies to fuel oxidative phosphorylation [5, 38], serving as an alternative to glucose and fatty acids for ATP production. However, 3-OHB can also influence cell functions via actions on the G-protein-coupled hydroxy- ...
3.1. Ketone Bodies Protected the Hearts against LPS-Induced Acute Myocardial Injury and Cardiac Dysfunction Male C57BL/6 J mice were exposed to LPS (20 mg/kg, i.p.) to induce septic cardiomyopathy, as described previously [5, 8]. In the KE pretreatment group, an almost two-fold incr...
Ketone bodies synthesized de novo by liver are (1) catabolized in mitochondria of extrahepatic tissues to acetyl-CoA, which is available to the TCA cycle for terminal oxidation (Figure 1A), (2) diverted to the lipogenesis or sterol synthesis pathways (Figure 1B), or (3) excreted in the ...
Figure 1. Metabolic Pathways of Ketone Bodies in Liver and Extrahepatic Organs Fatty acids are transported to mitochondria by carnitine palmitoyltransferase 1 (CPT1) and subsequently, ketone bodies acetoacetate (AcAc), beta-hydroxybutyrate (βOHB) and acetone are synthesized from acetyl-CoA that is ...