Ketone bodies are synthesized in the liver and kidney cortex and are used by most other tissues as an important source of energy.doi:DOI: 10.1016/B0-12-475570-4/01447-5Oliver E. OwenRichard W. HansonEncyclopedia of Endocrine Diseases
In subject area: Biochemistry, Genetics and Molecular Biology The so-called ketone bodies are a group of three compounds (acetoacetate, 3-hydroxybutyrate, and acetone) that are normally present in the circulation. From: Trends in Biochemical Sciences, 2019 ...
The ketone bodies acetoacetate (AcAc), D-β-hydroxybutyrate (D-βOHB), and acetone are primarily synthesized in the mitochondrial matrix of hepatocytes proportional to rates of adipose tissue lipolysis and hepatic fat oxidation. The isoform of 3-hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) in hep...
Twitter Google Share on Facebook (redirected fromSynthesis and degradation of ketone bodies) Thesaurus Medical Encyclopedia ke·tone (kē′tōn′) n. 1.Any of a class of organic compounds, such as acetone, characterized by having a carbonyl group in which the carbon atom is bonded to two othe...
3) Ketone derivatives play a very active role in photosynthesis as a a number of chemicals utilized/produced in the process are ketones4) In medical science, carbohydrates and amino acids produce ketone bodies viz. Acetoacetate and hydroxybutyrate...
Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful metabolic by-products when discovered in the mid-19th century in the urine of patients with diabetic ketoacidosis. It took physicians many years to realize that KBs are normal metabolites synthesized by the liv...
With the exception of potential diversion of ketone bodies into nonoxidative fates (see Nonoxidative Metabolic Fates of Ketone Bodies), hepatocytes lack the ability to metabolize the ketone bodies they produce. Ketone bodies synthesized de novo by liver are (1) catabolized in mitochondria of extrahepa...
These results suggest that malignant hepatocytes, as a consequence of their production and release of large quantities of cholesterol, derive metabolic advantage over neighboring normal hepatocytes by being able to consume ketone bodies synthesized by normal cells in response to the elevated cholesterol ...
27, 28, 29, 30 One metabolic therapy with promise in this area is the induction of a state of ketosis, where blood ketone body concentrations are elevated. Ketone bodies are endogenous molecules synthesized from free fatty acids. The primary ketone body, beta-hydroxybutyrate (BHB), directly ...
Ketone bodies cannot be utilized by liver, hence they can not be used to synthesize either triglycerides or cholesterol. Triglycerides and cholesterol are synthesized either from carbohydrates or lipids, which provide acetyl CoA, and thence respectively malonyl CoA or HMG CoA for the two synthetic pa...