There was no correlation between the leucocyte count and any pharmacokinetic parameter for ketoconazole. Variation in AUC was 20-fold on the 200 mg daily dose and 8-fold on the 400 mg per day regimen. Measurement of serum levels during ketoconazole treatment appears necessary in view of the ...
The dosage was reduced to 200 mg when a cure was achieved. The duration of treatment ranged from two to 18 months. Results of treatment were classified as very good (clinical and serologic cure) in 23 (41%) of the patients; good (clinical cure only) in 28 (50%); fair (partial ...
200 mg once daily. Dosage may be increased to 400 mg once daily if expected clinical response not achieved.Do not exceed recommended dosage; higher dosage associated with increased toxicity. (See Cautions.)Manufacturer states usual duration of treatment for systemic fungal infections is 6 months; ...
Ketoconazole, a drug used principally for treatment of mycotic disease, inhibits the first step in cortisol biosynthesis (cholesterol side-chain cleavage to pregnenolone) and, to a lesser extent, the conversion of 11-deoxycortisol to cortisol. Although ketoconazole has been used successfully in both ...
Uses for Xolegel XOLEGEL is indicated for the topical treatment of seborrheic dermatitis in immunocompetent adults and children 12 years of age and older. Safety and efficacy of XOLEGEL for treatment of fungal infections have not been established. ...
6. Ketoconazole has a very poor capability of penetrating blood-brain barrier and is not suitable for the treatment of fungal meningitis. This product also has poor efficacy in treating Aspergillus, Mucor or maduromycosis and thus is also not suitable. ...
The usual duration of therapy for systemic infection is 6 months. Treatment should be continued until active fungal infection has subsided. Adults The recommended starting dose of ketoconazole tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient ...
Comparison of fluconazole and ketoconazole for oropharyngeal candidiasis in AIDS. In a randomised, double-blind study the efficacy and toxicity of oral fluconazole 50 mg daily and ketoconazole 200 mg daily were compared for the treatment... S De Wit,H Goossens,D Weerts,... - 《Lancet》 被引...
Stir at 100 °C overnight with the reaction product resulting in 3.2 parts ketoconazole after treatment. Category Toxic substances Toxicity grading Highly toxic Acute toxicity Oral-rat LD50: 166 mg/kg; Oral-Mouse LD50: 618 mg/kg. Flammability and hazardous characteristics It is combustible ...
Indications and Usage for Ketoconazole Shampoo Ketoconazole shampoo, 2%, is indicated for the treatment of tinea (pityriasis) versicolor caused by or presumed to be caused by Pityrosporum orbiculare(also known as Malassezia furfur or M. orbiculare). Note: Tinea (pityriasis) versicolor may give ri...