Monoaminergic antidepressants have a delay in the onset of response that needs alternatives. Sub anesthetic doses of ketamine, a NMDA receptor antagonist, show a rapid-acting antidepressant effect in Major Depressive Disorder (MDD) and in bipolar depression, and improve suicidal ideation. However, ...
particularly for cases with TRD including MDD and bipolar disorder (BD) [8,9,10,11,12,13,14,15,16,17,18,19,20]. One of the most notable features of ketamine in treating depression is its rapid onset of action. Unlike current antidepressants that...
The onset of action of ketamine is rapid; an intravenous dose of 2 mg/kg of body weight usually produces surgical anesthesia within 30 seconds after injection, with the anesthetic effect usually lasting five to ten minutes. If a longer effect is desired, additional increments can be administered...
The onset of action of ketamine hydrochloride is rapid; an intravenous dose of 2 mg/kg (1 mg/lb) of body weight usually produces surgical anesthesia within 30 seconds after injection, with the anesthetic effect usually lasting five to ten minutes. If a longer effect is desired, additional inc...
(HealthDay)—Ketamine has rapid-onset antidepressant action, although the mechanism of its positive effect is currently unclear, according to research published online Dec. 26 in the Journal of Clinical Pharmacy and Therapeutics.
Ketamine induces rapid onset of antidepressant action: neurophysiological biomarkers as predictors of effect. Quevedo J,Comim CM,Gavioli EC.Ketamine induces rapid onset of antidepressant action:neurophysiological biomarkers as predictors of effect. Biomark Med . 2009......
Early work in this area, however, found that few NMDAR antagonists and modulators had clinical success, failing to replicate ketamine’s broad therapeutic profile and rapid onset of robust antidepressant effects. For example, non-specific NMDAR antagonists such as memantine had extremely varied results...
Nielsen[73] suggested that a sufentanil and ketamine nasal spray provides a rapid onset of analgesia for a variety of painful procedures with few adverse effects and has promis- ing features for use in pediatric procedural pain management. A prospective, randomized, double-blind study that included...
Ketamine when sweetened with a soda drink appears to be palatable with a rapid onset of action and few side effects. Thus ketamine given orally may be a cheaper and more accessible option for effective pain-relief in the emergency room. There is a need to conduct more studies on a larger ...
we show that the sustained behavioral effects of ketamine are mediated by a decrease in BMP signaling and an increase in AHN, without selectively altering the activity of immature neurons. By contrast, the rapid onset effects are ketamine have been shown to reflect the increased activity of immatu...