Maintenance:The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia. ...
Ketamine has a rapid onset and short half-life, can be administered in various formulations, and delivers sedation reliably with a single dose. However, providing a well-defined dose of ketamine for acute agitation, particularly as an intravenous (IV) bolus, is questionable. This study aims to...
This agent is a lipid soluble compound, has an initial rapid distribution and large volume of distribution, with a half-life of 10 to 15 minutes. Secondarily, the drug distributes into peripheral tissues with a slower elimination half-life of up to 3 hours, undergoes hepatic metabolism and is...
Following intravenous administration, the ketamine concentration has an initial slope (alpha phase) lasting about 45 minutes with a half-life of 10 to 15 minutes. This first phase corresponds clinically to the anesthetic effect of the drug. The anesthetic action is terminated by a combination of r...
Elimination:Following IV administration, ketamine redistributes from the CNS to peripheral tissues. Its elimination half-life is typically 2 to 4 hours. After administration, most ketamine and metabolites are excreted through urine, with 91% of administered radioactivity appearing over 5 days. Only abou...
Ketamineis water soluble at the pH of intravenous preparations but becomes highly lipid soluble in the bloodstream, resulting in a rapid onset of effect within 1 minute of intravenous administration. Likefentanyl, ketamine has a rapid initial redistribution half-life (t1/2α) of 7 minutes and a...
“ketamine is a really effective, potentially lifesaving, treatment for the right patients, but not everyone is a good candidate for it,” she said. “as psychiatrists, we need to ensure this treatment is being delivered in a way that benefits patients while preventing harm.” mor...
Nanjing 210029, China; 2Department of Anesthesiology and Pain Medicine, University of California Davis Health System, Sacramento, CA 95817, USA After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pai...
Following intravenous administration, the ketamine concentration has an initial slope (alpha phase) lasting about 45 minutes with a half-life of 10 to 15 minutes. This first phase corresponds clinically to the anesthetic effect of the drug. Elimination Metabolism Ketamine is metabolized via N-deal...
The plasma half-life of i.p. administered ketamine in mice ranges from ~15 to 25 min [53,54], and 10 mg/kg of ketamine impaired locomotion in C57BL/6 mice 15 min after injection [55]. Nevertheless, consistent with Wei et al.’s study on adolescent males [48], we observed no ...